代谢功能障碍相关的脂肪性肝病与侵蚀性食道炎发展的关联:一项纵向观察性研究
Masahiro Sogabe1,2, Toshiya Okahisa1,2, Miwako Kagawa2
1Department of Gastroenterology and Oncology, Tokushima University Graduate School of Biomedical Sciences, Tokushima, Japan.
与代谢功能障碍相关的脂肪性肝病 (MASLD) 增加了患侵蚀性食道炎 (EE) 的风险,特别是在男性和老年人中. 50岁以上的MASLD患者具有多个组成部分,面临更高的EE风险.
科学领域:
- 胃肠病学 胃肠病学
- 肝病学 肝病学是一种肝病学.
- 内部医学 内部医学
背景情况:
- 侵蚀性食道炎 (EE) 与代谢失调和脂肪肝有关.
- EE与代谢功能障碍相关的脂肪性肝病 (MASLD) 之间的特定关联需要进一步调查.
研究的目的:
- 纵向研究MASLD与EE发展之间的关联.
主要方法:
- 在基线没有EE的1578名患者被随访超过2年,进行多次健康检查.
- 一般化的估计方程分析了MASLD和EE之间的纵向关联.
主要成果:
- 在14.5%的男性和7.2%的女性中,EE发生.
- 在生活方式调整后,MASLD与男性的EE风险增加有关 (OR 1.907),但在女性 (OR 1.483) 没有显著增加.
- 在年龄≥50岁,MASLD成分≥3个的个体中,MASLD在男性 (OR 2.408) 和女性 (OR 2.148) 中显著增加了EE风险.
结论:
- MASLD对EE发育的影响因性别和年龄而异.
- 患有MASLD的老年人 (≥50岁),特别是具有多个代谢成分的老年人,患EE的风险较高,需要密切监测.
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