肠道微生物群的发展与在流行病相关的社交距离限制期间出生的婴儿的过敏之间的关联
Katri Korpela1,2, Sadhbh Hurley3,4, Sinead Ahearn Ford2
1Human Microbiome Research Program, Faculty of Medicine, University of Helsinki, Helsinki, Finland.
Allergy
|February 29, 2024
概括
减少微生物暴露可能会增加过敏. 该研究发现,植物性食品和垂直传播的细菌,而不是环境微生物,是婴儿微生物群发育和过敏预防的关键.
科学领域:
- 微生物学 微生物学
- 免疫学 免疫学 免疫学
- 儿科 儿科 儿科
背景情况:
- 假设减少微生物暴露会增加过敏患病率.
- 随着COVID-19大流行和相关的社交距离,提供了一个独特的机会来研究早期生命中的微生物暴露.
- 为了研究这些因素,建立了CORAL (儿童,喘和减少环境) 队列.
研究的目的:
- 确定影响婴儿微生物群发育的环境暴露和饮食因素.
- 检查早期生命微生物群与过敏结果之间的关联.
- 为了比较在社交距离期间婴儿的微生物群和过敏患病率与大流行前的队列.
主要方法:
- 在6个月和12个月的婴儿便样本的16S rRNA基因测序.
- 与公布的16S数据进行比较,这些数据来自于大流行前的队列.
- 在线调查问卷用于流行病学,饮食和健康数据的收集.
- 皮肤刺伤测试 (SPT) 和评估12个月和24个月的亚托皮炎和食物过敏.
主要成果:
- 与之前的队伍相比,珊瑚婴儿的Bifidobacteria数量较高,Clostridia数量较低.
- 环境微生物暴露与Clostridia种群的丰富度相关.
- 断奶期间的植物性食物对微生物群的发展产生了积极的影响.
- 更高的Bifidobacteria和丁酸盐生产者与较低的亚托皮炎 (AD) 风险和SPT阳性相关.
- 与大流行前水平相比,过敏原敏感性,食物过敏和AD患病率没有增加.
结论:
- 环境暴露和饮食显著塑造婴儿微生物群.
- 垂直传播的细菌和适当的饮食支持似乎比一般环境微生物暴露对过敏保护更为关键.
- 研究结果表明,理解婴儿时期的过敏预防策略可能会发生转变.
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