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多光谱单点氧发光剂量测量 (MSOLD) 用于以光介导的光动力学疗法

Weibing Yang¹, Vivek Rastogi¹, Hongjing Sun¹

¹Department of Radiation Oncology, University of Pennsylvania, Philadelphia, PA 19104.

Proceedings of SPIE--the International Society for Optical Engineering

|February 29, 2024

概括

这项研究优化了光动力学疗法 (PDT) 的多谱单片氧剂量测量 (MSOLD),通过提高信号与噪声比. 增强的MSOLD方法在PDT应用中显示出准确的单点氧检测的前景.

科学领域:

生物医学光学生物医学光学
光动力学疗法光动力学疗法
医学物理医学物理

背景情况:

单片氧 ([¹O₂) 的直接检测对于II型光动力学治疗 (PDT) 剂量测量至关重要.
目前的多光谱单片氧剂量测量 (MSOLD) 面临着由于单片氧信号的弱小和短暂而带来的挑战,需要改进信号噪声比.

研究的目的:

为了优化MSOLD信号采集,提高灵敏度和最小可检测性.
在各种体外条件下对单点氧显式剂量计 (SOED) 进行改进的MSOLD方法的验证.
为了准备在小鼠瘤模型中对MSOLD设备进行体内测试.

主要方法:

使用光纤检测和PDT治疗光的直角布局.
使用632nm激光和InGaAs探测器进行信号收集.
在1200-1300纳米的光谱辐射测量,然后进行背景减去和高斯适配,用于单个氧气信号量化.

主要成果:

该研究的重点是优化MSOLD信号采集并验证其灵敏度和最小可检测性.
将MSOLD信号与基于体内测量的单片氧显式剂量计 (SOED) 结果进行比较.
成功开发和验证了一种改进的MSOLD技术,用于单点氧气检测.

结论:

优化的MSOLD方法为PDT中直接单点氧气检测提供了改进的信号噪声比.
这一进步对于在II型PDT中准确的剂量测量至关重要.
经过验证的MSOLD设备已经准备好在临床前PDT模型中进行体外测试.

关键词:

在InGaAs的基础上,在MSOLD中使用MSOLD.在PDT中使用PDT.多光谱发光剂量计 (MSOLD) 是一种多光谱发光剂量计.从内部拍摄的照片单一氧显式剂量计 (SOED) 是一种单一氧显式剂量计.

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