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早产婴儿肠道微生物与儿童行为尺度的关系:初步见解
Samia Valeria Ozorio Dutra1,2,3, Anujit Sarkar2,3, Ji Youn Yoo2,3
1Nancy Atmospera-Walch School of Nursing, University of Hawaii at Manoa, Honolulu, HI, United States.
Frontiers in nutrition
|February 29, 2024
概括
在出生时体重非常低的婴儿中,肠道微生物组的改变与4岁时的行为问题有关. 像Veillonella dispar和Escherichia coli这样的特定细菌显示出与儿童后期行为的关联.
科学领域:
- 微生物学 微生物学
- 发展心理学 发展心理学
- 新生儿医学 新生儿医学
背景情况:
- 非常低出生体重 (VLBW) 的婴儿面临肠道失调和神经发育缺陷的风险.
- 与VLBW婴儿微生物失生症相关的微妙行为影响需要进一步调查.
- 在VLBW婴儿中早期肠道微生物组失调的长期神经行为后果尚未完全理解.
研究的目的:
- 探索VLBW婴儿的肠道微生物组与他们在4岁时的行为之间的联系.
- 识别与幼儿时代行为结果相关的特定细菌种群.
- 在VLBW发展的背景下,为了解肠-大脑轴做出贡献.
主要方法:
- 利用儿童行为检查清单 (CBCL) 来评估4岁儿童的行为领域.
- 采用了线性模型 (MaAsLin) 的正规相关性分析 (CCA) 和多变量分析,将肠道微生物群数据与行为评分联系起来.
- 纠正了潜在混因素的CBCL得分,包括妊娠年龄,出生体重和败血症.
主要成果:
- 确定了特定肠道细菌 (例如,Veillonella dispar,Enterococcus,Escherichia coli,Ruminococcus) 和4年后的行为之间的统计学上显著的关联.
- 观察到早期肠道细菌与情感,焦虑和注意力缺陷/多动性领域之间的联系.
- 在早期的肠道微生物群α多样性和4年的行为测量之间没有发现显著的关联.
结论:
- 初步数据表明,VLBW肠道微生物组失调和儿童行为之间存在关系.
- 这项研究突出了可能影响VLBW个体神经行为发育的特定细菌种群.
- 这些发现支持对肠道微生物组合的检查,以了解VLBW种群的行为发展.
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