再组合人体原蛋白的组织工程应用:最近进展的回顾
Lili Cao1, Zhongfeng Zhang1, Dan Yuan1
1Department of Plastic Surgery, Zhejiang Rongjun Hospital, Jiaxing, Zhejiang, China.
Frontiers in bioengineering and biotechnology
|February 29, 2024
概括
再组合人体原在伤口愈合和骨科方面表现有前途. 本综述探讨了其应用和3D打印,以提高治疗效果和再生医学的进步.
科学领域:
- 生物材料科学 生物材料科学
- 合成生物学 合成生物学
- 再生医学是一种再生医学.
背景情况:
- 再组合人体原是一种新型生物材料,在医学上具有显著的潜力.
- 应用包括伤口愈合,肌层再生和骨科.
- 有效提供最佳治疗结果仍然是一个挑战.
研究的目的:
- 为生物医学系统中复合人体原蛋白应用提供全面的概述.
- 为了解决提供用于治疗用途的重组人体原蛋白的挑战.
- 探索使用重组原蛋白进行再生修复的3D打印技术.
主要方法:
- 对复合人体原蛋白应用的文献综述.
- 分析生物材料交付当前的挑战.
- 探索3D打印与重组原体的整合.
主要成果:
- 再组合人体原蛋白是一种多功能生物材料,可用于各种医疗应用.
- 输送方法和3D打印是释放治疗潜力的关键.
- 进步对于增强再生生物材料和患者结果至关重要.
结论:
- 再组合人体原对再生医学具有重大前景.
- 优化交付和利用3D打印等技术至关重要.
- 生物材料的进一步创新将改善治疗方法和患者护理.
相关概念视频
01:13Protein Organization
Overview
02:41Protein Complex Assembly
Proteins can form homomeric complexes with another unit of the same protein or heteromeric complexes with different types. Most protein complexes self-assemble spontaneously via ordered pathways, while some proteins need assembly factors that guide their proper assembly. Despite the crowded intracellular environment, proteins usually interact with their correct partners and form functional complexes.
Many viruses self-assemble into a fully functional unit using the infected host cell to...
Many viruses self-assemble into a fully functional unit using the infected host cell to...
02:41Protein Complex Assembly
Proteins can form homomeric complexes with another unit of the same protein or heteromeric complexes with different types. Most protein complexes self-assemble spontaneously via ordered pathways, while some proteins need assembly factors that guide their proper assembly. Despite the crowded intracellular environment, proteins usually interact with their correct partners and form functional complexes.
Many viruses self-assemble into a fully functional unit using the infected host cell to...
Many viruses self-assemble into a fully functional unit using the infected host cell to...
01:14Introduction to Nuclear Reprogramming
Nuclear reprogramming is the process of switching gene expression of one cell type to that of another cell type, usually from a differentiated cell state to an undifferentiated cell state. Differentiation occurs during processes such as development and morphogenesis, tissue regeneration, and malignancy. Cells can also be artificially induced to reprogram their gene expression by techniques such as nuclear transfer, induced pluripotency, and cell fusion. Such techniques have many applications in...
01:24Methods of Nuclear Reprogramming
Nuclear reprogramming is a process of transforming one cell type into an unrelated cell type by epigenetic changes that alter the cell’s original gene expression pattern. Such epigenetic changes force cells to express a different set of genes, which play a significant role in inducing transformation into other cell types. Nuclear reprogramming offers applications in reproductive cloning for livestock propagation and regenerative medicine — developing patient-specific cells for injury repair.
01:24Protein Organization
Proteins are polymers of amino acid residues. They are versatile and responsible for different cellular functions, including DNA replication, molecular transport, catalysis, and structural support. Proteins have a hierarchical structure comprising at least three levels of organization: primary, secondary, and tertiary structure. Some large proteins have a quaternary structure where individual protein subunits are linked together.
The primary structure of a protein is its amino acid sequence.
The primary structure of a protein is its amino acid sequence.