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使用近红外光谱学在左心室进行了强大的,高密度的病变映射

Haiqiu Yang¹, Jonah A Majumder², Ziyi Huang¹

¹Columbia University, Department of Electrical Engineering, New York, United States.

Journal of biomedical optics

|February 29, 2024

概括

近红外光谱 (NIRS) 精确检测血液中的射频除 (RFA) 病变,克服了评估心房动治疗的局限性. 这种光学技术为体内程序提供可靠的反.

科学领域:

心血管切除技术的使用.
生物医学光学生物医学光学
医疗器械开发医疗器械开发

背景情况:

对于心房动的射频除 (RFA) 往往由于评估除程度的挑战而失败.
光学光谱学,包括近红外光谱学 (NIRS),显示了评估RFA损伤形成的潜力.
目前的光学方法在体内条件下缺乏验证,这限制了它们的临床适用性.

研究的目的:

为了验证以导管为基础的NIRS,以评估在真实环境中模仿条件下的猪心房的RFA病变形成.
为了证明在血液和各种冲击角度的光谱衍生的光学指数的准确性.
评估NIRS在RFA程序期间实时反的可靠性.

主要方法:

一个定制的NIRS导管被用来绘制猪左心房的图谱.
在酸盐缓冲盐水 (PBS) 和猪血中进行了NIRS测量.
一个随机的森林模型被训练来根据NIRS数据预测病变.

主要成果:

在NIRS测量中,最少的角度依赖度高达60度.
随机森林模型在病变预测方面取得了高准确性 (灵敏度为81.7%,特异性为86.1%,AUC为0.921).
在PBS和血液中比较病变地图显示出高度相似性 (平均SSI为0.749,平均NIP为0.867).

结论:

基于导管的NIRS可以准确地检测血液中沉浸的左心室的RFA病变.
从NIRS获得的光学参数在血液和非垂直角度是可靠的.
NIRS为体内RFA程序提供了有价值的实时反,有可能改善心房的治疗结果.

关键词:

生物医学光学生物医学光学心脏的剥离是心脏的剥离.心脏电生理学心脏电生理学接近红外光谱学近红外光谱学

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