与阿片类药物使用障碍患者之间的注意力,冲动性和执行功能进行比较:与健康对照者相比,布普伦诺芬维持治疗与活跃使用者相比,与健康对照者相比
Didem Beşikci Keleş1, Rabia Bilici1, Batuhan Ayık1
1Department of Psychiatry, Erenkoy Mental and Nervous Diseases Training and Research Hospital, Istanbul, Erenkoy, Turkey.
Indian journal of psychiatry
|February 29, 2024
概括
阿片类药物使用障碍 (OUD) 会导致注意力和执行功能的显著神经认知障碍. 即使在维持治疗期间,这种损伤也会持续下去,这凸显了长期OUD治疗计划的必要性.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 成 药物 药物 药物 药物
背景情况:
- 阿片类药物使用障碍 (OUD) 影响全球超过1600万,亚洲的高率.
- OUD与神经认知障碍有关,影响决策,应激反应和行为调节.
- 了解OUD认知缺陷对于有效的治疗策略至关重要.
研究的目的:
- 为了比较土耳其男性的神经认知功能,活跃的OUD,缓解布普伦诺芬/纳洛维护 (BMT) 和健康的对照 (HC).
- 用剑桥神经心理测试自动化电池 (CANTAB) 来评估注意力,冲动性和执行功能.
主要方法:
- 横截面研究比较了三个组:活跃的OUD (n=40),在BMT上缓解的OUD (n=41) 和健康的对照 (n=43).
- 使用剑桥神经心理测试自动化电池 (CANTAB) 进行全面的神经认知评估.
- 专注于持续注意力,冲动性 (认知和运动) 和执行功能的测量.
主要成果:
- 与健康对照组相比,活跃的OUD和BMT组在持续的注意力,冲动性和执行功能方面表现出显著的损伤.
- 在活跃的OUD组和BMT组之间没有观察到神经认知表现的显著差异.
- 这些发现表明,在OUD患者中,无论治疗状态如何,神经认知缺陷仍然存在.
结论:
- 患有OUD的个体表现出神经认知损伤,这种损伤没有得到布普伦诺芬/纳洛维持治疗的改善.
- 神经认知缺陷应该是OUD患者长期治疗计划的关键考虑因素.
- 需要进一步的研究来探索可能解决这些持续性认知障碍的干预措施.
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