在精神分裂症中,城市教育与功能性大脑连接之间的关联
Vittal Korann1,2, Umesh Thonse3, Ranjini Garani4,5
1Schizophrenia Division, Centre for Addiction and Mental Health (CAMH), Toronto, ON, Canada.
Indian journal of psychiatry
|February 29, 2024
概括
城市的成长影响了精神分裂症患者和健康个体的大脑连接. 这项研究揭示了受影响的特定大脑区域,为精神分裂症提供了洞察力.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 环境健康 环境健康
背景情况:
- 城市成长是一个已知的精神分裂症 (SCZ) 风险因素.
- 将城市环境与SCZ联系起来的生物机制尚不清楚.
- 城市化对SCZ中大脑连接的影响尚未研究.
研究的目的:
- 调查城市出生和成长以及功能性大脑连接之间的关联.
- 在SCZ患者和健康志愿者 (HV) 中探索这些关联.
主要方法:
- 三项研究的二次分析 (87名SCZ患者,70名HV).
- 计算一个发展的城市城市指数.
- 休息状态功能磁共振成像 (fMRI) 与种子感兴趣区域 (ROI) 连接性分析.
主要成果:
- 在SCZ患者和HV患者的城市化和功能连接之间发现了显著的关联.
- 在SCZ患者中,城市化与包括尾状,ACC和杏仁体在内的区域的连接性相关.
- 受影响的地区参与奖励处理和社会认知.
结论:
- 城市出生和成长显著影响SCZ的功能性大脑连接.
- 这些发现突出了城市化在SCZ病理生理学中的作用.
- 评估社会认知可以提高对SCZ障碍的理解.
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