米R-128-3p - 人类中枢神经系统的灰色突出物
Klaudia Kiel1, Sylwia Katarzyna Król2, Agnieszka Bronisz1
1Tumor Microenvironment Laboratory, Mossakowski Medical Research Institute, Polish Academy of Sciences, 5 Pawińskiego Street, Warsaw, Poland.
Molecular therapy. Nucleic acids
|February 29, 2024
概括
微RNA-128-3p对大脑功能和发育至关重要. 它的耗尽与质母细胞瘤有关,这表明它有可能成为治疗脑瘤和神经系统疾病的治疗剂.
科学领域:
- 神经科学是一个神经科学.
- 分子生物学分子生物学
- 在瘤学瘤学.
背景情况:
- 微RNA-128-3p (miR-128-3p) 是人类中枢神经系统中基因表达的关键调节者.
- miR-128-3p的失调与神经退行性疾病,脑损伤和癌症有关.
- 在质母细胞瘤中,miR-128-3p显著耗尽,这是一种高度侵略性的脑瘤.
研究的目的:
- 审查miR-128-3p在神经发生和疾病中的多方面的作用.
- 探索miR-128-3p作为神经疾病和癌症治疗点的潜力.
- 要突出miR-128-3p在大脑发育和功能中的重要性.
主要方法:
- 对miR-128-3p.p.现有研究的文献综述.
- 对miR-128-3p参与细胞和分子通路的分析.
- 关于miR-128-3p在疾病发病和治疗潜力的作用的综合数据.
主要成果:
- miR-128-3p在维持神经元系细胞和大脑功能方面发挥着至关重要的作用.
- 改变miR-128-3p的水平与各种神经病理有关,包括质母细胞瘤.
- miR-128-3p具有作为大脑癌症的生物标志物和治疗剂的潜力.
结论:
- miR-128-3p对于正常的大脑发育和功能至关重要.
- 它的失调有助于恶性和神经退行性疾病的发病.
- 向miR-128-3p为质母细胞瘤和其他神经系统疾病提供了有前途的治疗策略.
相关概念视频
01:04Glial Cells
Overview
01:20Anatomy of the Brain: Major Regions
The brain is the most complex organ in the human body. It consists of four main parts: the cerebrum, diencephalon, cerebellum, and brainstem.
The cerebrum is the largest section of the brain and divides into left and right hemispheres, separated by a deep fissure. The cerebral outer layer of grey matter — the cerebral cortex — comprises elevations called gyri and shallow groves called sulci. The inner portion of white matter includes long nerve fibers known as axons, which connect various areas...
The cerebrum is the largest section of the brain and divides into left and right hemispheres, separated by a deep fissure. The cerebral outer layer of grey matter — the cerebral cortex — comprises elevations called gyri and shallow groves called sulci. The inner portion of white matter includes long nerve fibers known as axons, which connect various areas...
01:11Cerebrum: Anatomical Overview II
Each cerebral hemisphere can be divided into three main regions. The outermost region, the cerebral cortex, is a thin layer (2 to 4 millimeters thick) made up of gray matter, consisting of neuron cell bodies, dendrites, glial cells, and blood vessels. The middle region, or white matter, is primarily composed of myelinated nerve fibers organized into three types of large tracts: association fibers, commissures, and projection fibers. Association fibers connect different areas within the same...
01:17Cerebellum: Anatomical Regions
The cerebellum, also known as the "little brain," is located in the posterior cranial fossa, inferior to the tentorium cerebelli and dorsal to the brainstem. It plays a significant role in motor control, coordination, and proprioception.
Cerebellar Structure
Externally, the cerebellum features a highly convoluted surface with numerous folia (narrow ridges) separated by shallow sulci (grooves). The cerebellum is divided into two hemispheres by a thin median structure known as the vermis. The...
Cerebellar Structure
Externally, the cerebellum features a highly convoluted surface with numerous folia (narrow ridges) separated by shallow sulci (grooves). The cerebellum is divided into two hemispheres by a thin median structure known as the vermis. The...
01:19Brainstem
The brainstem, located inferior to the brain and superior to the spinal cord, serves as a bridge between the cerebrum and the spinal cord. It plays a vital role in relaying information and controlling critical life functions. It comprises three primary regions: the midbrain, pons, and medulla oblongata.
The Midbrain
The midbrain is located beneath the diencephalon and connects the cerebrum with the lower parts of the brain. The cerebral peduncles are prominent midbrain structures that house the...
The Midbrain
The midbrain is located beneath the diencephalon and connects the cerebrum with the lower parts of the brain. The cerebral peduncles are prominent midbrain structures that house the...
01:21Brainstem: Control Centers of Medulla
The medulla oblongata is a crucial part of the brainstem responsible for controlling various autonomic and involuntary functions. It contains several nuclei, including the olivary, cuneate, gracile, and solitary nuclei.
Olivary Nucleus
The olivary nucleus, or inferior olivary nucleus, is located within the ventrolateral part of the medulla oblongata. It is primarily involved in motor coordination and motor learning. The olivary nucleus receives input from the spinal cord, cerebellum, and motor...
Olivary Nucleus
The olivary nucleus, or inferior olivary nucleus, is located within the ventrolateral part of the medulla oblongata. It is primarily involved in motor coordination and motor learning. The olivary nucleus receives input from the spinal cord, cerebellum, and motor...