由内密封体诱导的基因毒性:一个系统的审查
Thiago Guedes Pinto1, Ana Claudia Muniz Renno1, Jean Nunes Dos Santos2
1Department of Biosciences, Institute of Health and Society, Federal University of São Paulo, UNIFESP, Santos, SP, Brazil.
The Saudi dental journal
|February 29, 2024
概括
牙内密封剂可能会导致DNA损伤,树脂基材料显示出最高的基因毒性潜力. 本系统性审查阐明了各种牙科密封剂的基因毒性在体外和体内.
科学领域:
- 牙科材料科学 牙科材料科学
- 分子生物学分子生物学
- 毒理学 毒理学 毒理学
背景情况:
- 内牙密封剂对于根管治疗至关重要.
- 了解它们的潜在基因毒性对于患者安全至关重要.
- 之前的研究已经产生了关于密封剂诱导的DNA损伤的各种结果.
研究的目的:
- 系统地审查和阐明内牙密封剂是否可以诱导DNA损伤.
- 评估各种内牙密封体类型的基因毒性潜力.
- 为了澄清内密封剂在口腔组织中导致DNA损伤的程度.
主要方法:
- 按照PRISMA 2020指南进行的系统审查.
- 包括23项评价内牙密封剂的研究.
- 基因毒性测定,材料类型和度水平的分析.
主要成果:
- 大多数内牙密封体表现出具有基因毒性潜力.
- 基于树脂的密封剂被确定为最具有潜在的基因毒性.
- 基因毒性结果受到测试类型,材料和度的影响.
结论:
- 内牙密封剂可以作为基因毒剂.
- 基于树脂的密封剂需要特别注意,因为它们具有基因毒性潜力.
- 提供了关于口腔组织中密封剂诱导的DNA损伤的进一步澄清.
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