患有头恶性瘤的患者在CPI治疗期间免疫相关不良影响的危险因素 - 一个单一中心研究
Frederic Jungbauer1, Annette Affolter1, Christoph Brochhausen2
1Department of Otorhinolaryngology, Head- and Neck-Surgery, University Medical Centre Mannheim, Heidelberg University, Mannheim, Germany.
对头癌的检查点抑制剂 (CPI) 可以引起与免疫相关的不良反应 (irAEs). 这项研究没有发现可靠的风险因素来预测irrAEs,强调患者教育和查这些并发症.
科学领域:
- 在瘤学瘤学.
- 免疫学 免疫学 免疫学
- 临床医学 临床医学
背景情况:
- 包括PD1抑制剂在内的检查点抑制剂 (CPI) 对晚期头癌至关重要.
- 免疫相关的不良反应 (irAEs) 是CPI治疗的重大并发症.
- 目前用于预测irAE风险的方法不足.
研究的目的:
- 调查人口统计学,组织病理学,临床或实验室值是否预测接受CPI治疗的头癌患者的irAEs.
主要方法:
- 对35名患者的回顾性分析,这些患者在头恶性瘤 (2018-2021) 中接受了尼沃卢马布或潘布罗利祖马布治疗.
- 评估基线特征与irAEs发生之间的关联.
主要成果:
- 37%的患者发生了irrAEs;肺炎是最常见的 (14%).
- 下T阶段与肺炎有关.
- 基础性白细胞增加与皮肤炎相关.
- 较高的CPS得分和较低的单细胞与甲状腺炎有关.
结论:
- 没有单一的人口统计学,组织病理学或实验室值可靠地预测irAEs.
- 患者需要对irAEs进行教育和敏感化.
- 定期对irAEs进行查对于早期发现和管理至关重要.
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