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与素相比,西对患有抑郁症患者代谢参数的影响:一项随机对照试验
Karthik Sankar1, Abdul Ajeed Mohathasim Billah1, Natrajan Shanmugasundram2
1Pharmacy, Sri Ramachandra Institute of Higher Education and Research, Chennai, IND.
Cureus
|February 29, 2024
概括
在患有严重抑郁症 (MDD) 的患者中,西比西更能改善代谢综合征 (MS) 标志物如葡萄糖和HDL. 两种药物都显示出类似的抑郁症缓解率,但没有显著影响血压.
科学领域:
- 精神病学是一个精神病学.
- 内分泌学 在内分泌学.
- 临床药理学 临床药理学
背景情况:
- 大型抑郁症 (MDD) 与代谢综合征 (MS) 的风险增加有关.
- 虽然已知非典型抗精神病药物会引起代谢障碍,但将选择性血清素再吸收抑制剂 (SSRI) 与MS联系起来的证据有限.
- 这项研究解决了需要了解通常处方的SSRI在MDD患者的代谢作用.
研究的目的:
- 为了比较患有重度抑郁症 (MDD) 的患者患有代谢综合征 (MS) 的风险,他们接受了西西丁治疗与西西丁治疗.
- 评估西和西对MDD患者关键代谢参数的影响.
主要方法:
- 一个前性的,开放的,随机对照试验,涉及122名MDD患者.
- 参与者被随机分配到接受20毫克的fluoxetine或10毫克的vortioxetine.
- 代谢综合征 (MS) 参数,包括禁食血葡萄糖 (FPG),甘油三 (TGs),高密度脂蛋白 (HDL),腰围,静脉血压 (SBP) 和透气血压 (DBP),在基线和24周内进行测量.
主要成果:
- 在24周前,西 (A组) 与西 (B组) 相比,FPG,HDL和腰围显著改善.
- 两组治疗均表现出类似的抑郁缓解率,由汉密尔顿抑郁评分表 (HAM-D) 评估.
- 两种药物都没有显著影响SBP或DBP,两者都与增加的TG水平有关,尽管观察到数值改善.
结论:
- 在改善MDD患者的特定代谢参数 (FPG,HDL,腰围) 方面,西似乎比西更有效.
- 伏尔托克塞丁和弗洛克塞丁都有效地实现了可比效率的抑郁症缓解.
- 需要进一步的研究,以了解长期的代谢影响和这些SSRI可能导致更高的TG水平.
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