美国成年人因各种原因和心血管疾病死亡率的性别差异:来自NHANES 2005-2018
Ying Lv1, Xiaodi Cao2, Kai Yu3
1Department of Cardiology, Shaanxi Provincial People's Hospital, Xi'an, Shaanxi, China.
Frontiers in cardiovascular medicine
|February 29, 2024
概括
男性的死亡率高于女性,尿酸水平显著介导了这种性别差异. 了解这些因素可以指导干预措施,以减少死亡率差异和改善公共卫生.
科学领域:
- 公共卫生 公共卫生
- 流行病学 流行病学
- 生物统计学 生物统计学
背景情况:
- 死亡率的性别差异是一个重大的公共卫生问题.
- 以前的研究发现了影响这些差异的生物学,社会和行为因素.
- 本研究调查了基于性别的死亡率变化的特定媒介.
研究的目的:
- 识别和量化导致所有原因死亡率性别差异的因素.
- 探索特定生物标志物在性别死亡率关联中的调解作用.
- 为有针对性的干预提供证据,旨在减少性别之间的死亡率差距.
主要方法:
- 来自国家健康和营养检查调查 (NHANES) (2005-2018) 的数据分析,涉及38,924名参与者.
- 收集有关人口统计,社会经济地位,生活方式,疾病状况和血清学指标的数据.
- 统计分析包括危险比率计算和调解分析,以评估尿酸的作用.
主要成果:
- 与女性相比,男性的全因和心血管死亡率较高.
- 调整后的危险比率表明,男性的死亡风险明显更高 (HRs从1.34到1.60不等).
- 尿酸水平被确定为一个重要的调解因素,解释了所有原因死亡率的性别差异的17.53%至27.47%.
结论:
- 死亡率的性别差异受到各种因素的复杂相互作用的影响.
- 尿酸水平在性别和死亡率之间的关联中发挥着关键的调解作用.
- 研究结果支持制定有针对性的公共卫生战略,以应对性别特异性死亡风险.
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