身体形状指数与帕金森病之间的关联:来自NHANESES的一项大型横截面研究
Wei Huang1, Yingqi Xiao2, Li Zhang2
1Department of Orthopaedics, The Sixth Affiliated Hospital, School of Medicine, South China University of Technology, Foshan, China.
Heliyon
|February 29, 2024
概括
较高的A体型指数与帕金森病风险增加有关. 这种关联在男性中更强烈,这表明身体成分会影响神经健康.
科学领域:
- 神经学 神经学
- 公共卫生 公共卫生
- 生物统计学 生物统计学
背景情况:
- 肥胖是一个日益关注的问题,具有复杂的健康影响.
- 帕金森病 (PD) 是一种进展性神经退行性疾病.
- 身体组成和PD风险之间的关系需要进一步调查.
研究的目的:
- 评估A体形指数 (ABSI) 与帕金森病风险之间的关联.
- 探索这种关联中潜在的性别特异性差异.
主要方法:
- 来自国家健康和营养检查调查 (2005-2018) 的31,933名成年参与者的分析.
- 参与者根据ABSI水平分为四分之一.
- 多因素后勤回归用于分析ABSI和PD之间的关系,调整人口因素.
主要成果:
- 与最低四分位数 (Q1) 相比,较高的ABSI (Q4) 与帕金森病的风险增加显著相关,即使经过对共变量进行调整 (OR=2.677,P<0.001).
- 亚组分析显示,与最高ABSI四分位数内的女性相比,男性的相关性更强[男性OR=6.563对比6.563]. 女性 OR=3.827].
结论:
- 成年ABSI和帕金森病风险之间存在非线性正相关性.
- 升高的ABSI是帕金森病的潜在危险因素,在20-59岁的男性中尤为明显.
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