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在接受心血管外科手术的患者中注射鼻内胰岛素的安全性:一项开放式,非随机化,剂量升级研究

Yosuke Nakadate^1,2, Akiko Kawakami¹, Takeshi Oguchi¹

¹Faculty of Medicine, Department of Anesthesiology, University of Yamanashi, Chuo, Yamanashi, Japan.

|February 29, 2024

概括

在心脏手术患者中,高达160 IU的鼻内胰岛素是安全的,没有观察到显著的低血糖症. 较高剂量可能会导致低血糖症,这表明由于剂量依赖的全身吸收,需要谨慎使用.

科学领域:

心脏病学心脏病学
内分泌学在内分泌学.
药理学药理学是指药理学的学科.

背景情况:

心脏手术患者可能会从外科手术期间的血糖控制中受益.
鼻内胰岛素提供了一种非侵入性胰岛素输送途径.
确定安全的鼻内胰岛素剂量对于临床应用至关重要.

研究的目的:

为了确定心脏手术期间鼻内胰岛素的最大安全剂量.
为了评估不断升级的鼻内胰岛素剂量的安全性和耐受性.

主要方法:

第1期,剂量升级临床试验,涉及接受心脏或主要血管手术的患者.
鼻内胰岛素 (0-240 IU) 或盐水后麻醉诱导的管理.
监测血糖水平以检测低血糖症 (<70 mg/dL).

主要成果:

在内鼻胰岛素剂量高达160 IU时,没有观察到低血糖症.
在240 IU组中的两名患者经历了低血糖.
160 IU的血清胰岛素水平升高,没有C升高.

结论:

在心脏手术患者中,注射高达160 IU的鼻内胰岛素是安全的,不会引起显著的低血糖症.
由于剂量依赖的全身吸收,建议谨慎使用160 IU鼻内胰岛素.
进一步的研究可能会探索鼻内胰岛素在这个人群中的治疗潜力.

关键词:

心脏外科手术的心脏手术低血糖症是一种低血糖症.内注射胰岛素的使用术后狂妄症的发生血清胰岛素度是血清中的胰岛素度.

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