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在怀孕期间接种第二次和第三次COVID-19疫苗后的产科和早期新生儿结果
Ravit Peretz-Machluf1, Mayan Gilboa2, Shiran Bookstein-Peretz1
1Department of Obstetrics and Gynecology, Sheba Medical Center, Tel Hashomer, Israel, Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
The Israel Medical Association journal : IMAJ
|February 29, 2024
概括
COVID-19增剂疫苗 (BNT162b2) 对孕妇是安全的,没有增加产科或新生儿不良结果. 怀孕期间的补充疫苗接种与较少的紧急剖腹产有关.
科学领域:
- 产科和妇科 产科和妇科
- 传染性疾病 传染性疾病
- 疫苗学 疫苗学 疫苗学
背景情况:
- 孕妇面临严重COVID-19的更高风险.
- 虽然关于两剂COVID-19疫苗的数据存在,但关于怀孕期间的强剂的信息有限.
- 广泛使用的mRNA疫苗是BNT162b2 (Pfizer/BioNTech) 的mRNA疫苗.
研究的目的:
- 为了比较接种COVID-19强剂疫苗的孕妇和仅接种两剂疫苗的孕妇的产科和新生儿早期结果.
- 在怀孕期间评估BNT162b2疫苗增剂的安全性和有效性.
主要方法:
- 一项横截面研究将两剂BNT162b2疫苗接种的孕妇与接种第三剂 (强剂) 的孕妇进行了比较.
- 分析的结果包括产科和早期新生儿参数.
主要成果:
- 84名孕妇接受了强剂,139名孕妇接受了两剂.
- 补充组在怀孕早期接受了疫苗 (212 vs 315 周).
- 没有观察到产科或新生儿结局的显著差异,除了助推组中较低的紧急剖腹产率 (aOR 0.21,P=0.039).
结论:
- 在怀孕期间使用BNT162b2COVID-19增剂疫苗是安全的.
- 补充疫苗接种不会增加产科或新生儿早期不良后果的发生率.
- 强剂量可能与减少紧急剖腹产的需求有关.
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