在健康的老年人中,运动期间的左心房储压力-体积关系
Stephen P Wright1,2, Jack M Goodman2,3, Zion Sasson2
1Centre for Heart, Lung and Vascular Health, University of British Columbia, Kelowna, British Columbia, Canada.
健康的成年人在运动期间显示左心房 (LA) 压力和体积增加. 这导致LA合规性降低,LA壁应力几乎翻了一番,突出体力活动期间的LA负荷.
科学领域:
- 心脏病学 心脏病学
- 身体生理学 身体生理学
- 心肺相互作用 心肺相互作用
背景情况:
- 左心室 (LA) 对于心肺相互作用至关重要,在心室静脉缩期间充当储水池.
- 了解LA储功能是理解心脏力学和肺血管相互作用的关键.
研究的目的:
- 通过分析肺动脉压 (PAWP) 和LA体积之间的相位关系来描述左心房 (LA) 储功能.
- 为了研究健康成年人炼期间LA压力,体积,服从性和壁面应力的变化.
主要方法:
- 在健康成年人中,用于测量PAWP与2D心声回声学以测量LA和左心室 (LV) 体积的右心脏导管结合.
- 测量了按节拍的PAWP波形 (A波,x波,V波,y波) 和LA体积 (最小,最大,收缩前) 在休息和运动期间.
主要成果:
- 运动增加了心率,中风量和心脏输出.
- 在运动期间,相位PAWP测量和LA填充增加,x-V压力脉冲翻了一番.
- LA最大和储备体积增加,而计算的LA合规性则略有下降 (6.8至4.8mL/mmHg).
- 估计LA墙壁应力在运动期间几乎翻了一番 (486到953mmHg·mL).
结论:
- 在健康的老年人中,次极限运动会导致PAWP波形的向上转移和扩大.
- 运动增加了LA填充,适度降低了LA遵守,并大大增加了估计的LA壁应力.
- 这些发现表明,运动期间左心房负荷显著,并提供了关于其在心肺相互作用中的作用的见解.
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