具有双相发作和晚期减少扩散的急性脑病变与同时发生的横向骨髓炎
Amanda Austin-Keiller1, Christine Saint-Martin2, Kenneth A Myers3,4,5
1Faculty of Medicine and Health Sciences, McGill University, Montreal, Quebec, Canada.
Epileptic disorders : international epilepsy journal with videotape
|February 29, 2024
概括
这项研究报告了一例罕见的急性脑病变,伴有双相发作和晚期减少扩散 (AESD),同时与儿童的横向髓炎. 早期的皮质类固醇治疗与剧烈的恢复相关,这表明潜在的共享免疫路径.
科学领域:
- 儿科神经学 儿科神经学
- 传染性疾病 传染性疾病
- 神经免疫学 神经免疫学
背景情况:
- 两相发作和晚期减少扩散 (AESD) 的急性脑病是一种罕见的神经疾病.
- 同时横侧髓炎是脊髓的炎症,通常表现为运动和感觉缺陷.
- 甲型流感感染与各种神经系统并发症有关.
研究的目的:
- 描述一个独特的AESD病例,同时发生在一个儿科患者的横体髓炎中.
- 调查AESD和横向肌底炎之间潜在的共享免疫机制.
- 为了评估急性皮质类固醇治疗在这种综合疾病中的疗效.
主要方法:
- 一个2岁女孩的病例报告呈现了AESD和横向髓炎的症状.
- 临床评估包括神经学检查和脑/脊柱MRI.
- 实验室调查包括自身免疫抗体面板 (MOG,AQP4,ENA).
- 用静脉注射甲基prednisolone进行治疗.
主要成果:
- 患者呈现出AESD特征,皮质失明和部横向肌炎,这些特征在A型流感之后出现.
- 脊柱MRI证实了横向髓炎;自身免疫标志物是负的.
- 患者在静脉注射甲基prednisolone治疗后显示出显著的临床改善.
- 介绍后六个月,患者恢复了她的神经学基线.
结论:
- 这是AESD与横体髓炎同时发生的第一个报告的病例.
- 这种共发生表明潜在的共享或重叠的免疫路径.
- 及时的皮质类固醇治疗可能有助于在这种复杂的神经表现中取得良好的结果.
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