SARS-CoV-2 感染与鼻微生物组的年龄和性别特异性变化有关
Silvia Bozza1, Emilia Nunzi1, Abel Frias-Mazuecos1
1Department of Medicine and Surgery, University of Perugia, 06132 Perugia, Italy.
Frontiers in bioscience (Landmark edition)
|February 29, 2024
概括
鼻子微生物组的组成随着年龄,性别和SARS-CoV-2感染而变化. 特定的细菌群体,如Lachnospiraceae在受感染的雌性中扩大,改变短链脂肪酸概况.
科学领域:
- 微生物学 微生物学
- 传染性疾病 传染性疾病
- 免疫学 免疫学 免疫学
背景情况:
- 随着COVID-19的流行,人们在了解空气传播感染病原体方面的差距变得明显.
- 鼻腔是呼吸道感染的关键部位,原因是SARS-CoV-2受体 (ACE2) 的高表达.
- 鼻腔微生物组在SARS-CoV-2相互作用中的作用及其保护性或有害功能的作用仍然不清楚.
研究的目的:
- 为了研究宿主因素和SARS-CoV-2感染对鼻微生物组组成的影响.
- 分析COVID-19患者微生物组变化和短链脂肪酸 (SCFA) 档案之间的关系.
主要方法:
- 从接受SARS-CoV-2检测的个人中收集了鼻口腔拭子样本.
- 使用16S rRNA测序分析了微生物组的组成.
- 短链脂肪酸 (SCFA) 用气色谱-质谱法进行测量.
主要成果:
- 鼻微生物组的组成受年龄,性别和SARS-CoV-2感染状态的影响.
- 感染SARS-CoV-2导致了特定的组成变化,包括感染女性的Lachnospirales-Lachnospiraceae的扩张.
- 这种扩张与分支和长链SCFA的水平降低相关.
结论:
- 鼻微生物组的改变与宿主因素和SARS-CoV-2感染有关.
- 在特定的患者群体中出现一致的微生物组模式.
- 这些发现可能会根据鼻腔微生物概况为COVID-19管理提供个性化医疗方法.
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