与学校年龄的行为和认知结果相关的动脉健康标志物
Romy Gonçalves1,2, Romy Gaillard1,2, Charlotte Cecil1,3
1The Generation R Study Group Erasmus University Medical Center Rotterdam The Netherlands.
Journal of the American Heart Association
|February 29, 2024
概括
早期的动脉健康测量,包括血压和动脉特征,与青少年行为或认知功能没有显著的关联. 需要进一步的研究来确定这些关系的关键年龄.
科学领域:
- 儿科心血管健康 儿童心血管健康
- 青少年的神经发育
- 血管生物学 血管生物学
背景情况:
- 动脉健康受损与成年人的认知衰退和精神病理学有关.
- 这项研究调查了这些关联是否在生命早期开始.
- 检查年轻人的动脉健康标志物,以发现行为和认知联系.
研究的目的:
- 检查动脉健康指标 (血压,动脉测量) 与青少年行为/认知之间的关联.
- 为了确定生命早期的动脉健康是否预测了青少年以后的结果.
- 研究血管健康对大脑影响的发育轨迹.
主要方法:
- 利用了来自荷兰R世代研究的数据,这是胎儿生命中的前性队列.
- 在10岁时测量了血压,动脉内脏介质厚度和动脉延伸能力.
- 在13岁时评估行为 (CBCL/6-18,SRS) 和认知功能 (WISC-V).
主要成果:
- 10岁时较高的平均动脉压暂时与较少的内化问题有关,但在多次测试校正后,这在统计学上并不显著.
- 在10岁时心动脉内膜厚度或心动脉延伸度与青少年行为或认知结果之间没有发现显著的关联.
- 注意缺陷多动症症状,自闭症特征和整体智商与测量的动脉健康参数无关.
结论:
- 该研究无法确定10岁时动脉健康与青春期早期的行为/认知结果之间的联系.
- 需要进一步的纵向研究来确定动脉健康对行为和认知的影响的关键发育时期.
- 这些发现表明,血管健康和神经发育之间的关系可能会在以后的生活中出现.
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