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Updated: Jul 2, 2025

A11-positive β-amyloid Oligomer Preparation and Assessment Using Dot Blotting Analysis
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A11-positive β-amyloid Oligomer Preparation and Assessment Using Dot Blotting Analysis

Published on: May 22, 2018

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氨基酸β-片段结合侧链林基聚合物作为利索酶氨基化症中强有力的抑制剂

Kasturee Nayak1, Pooja Ghosh1,2, Soumen Barman3

  • 1Polymer Research Centre and Centre for Advanced Functional Materials, Department of Chemical Sciences, Indian Institute of Science Education and Research Kolkata, Mohanpur, Nadia, West Bengal 741246, India.

Bioconjugate chemistry
|February 29, 2024
PubMed
概括

这项研究开发了使用粉样β-片段的新型-聚合物生物结合物,以抑制lyszyme amyloidosis. 与LVFF结合的聚合物有效抑制了粉样蛋白的形成,提供了一个有前途的治疗策略.

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A Tailored HPLC Purification Protocol That Yields High-purity Amyloid Beta 42 and Amyloid Beta 40 Peptides, Capable of Oligomer Formation06:34

A Tailored HPLC Purification Protocol That Yields High-purity Amyloid Beta 42 and Amyloid Beta 40 Peptides, Capable of Oligomer Formation

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Selection of Aptamers for Amyloid β-Protein, the Causative Agent of Alzheimer's Disease15:23

Selection of Aptamers for Amyloid β-Protein, the Causative Agent of Alzheimer's Disease

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相关概念视频

Amyloid Fibrils03:03

Amyloid Fibrils

Amyloid fibrils are aggregates of misfolded proteins.  Under most circumstances, misfolded proteins are either refolded by chaperone proteins or degraded by the proteasome. However, in the case of a mutation or a disease, these proteins can accumulate to form large clusters and often further assemble to form elongated fibers, called fibrils. 
Amyloid deposits were observed as early as 1639 in the liver and the spleen.   In 1854, Rudolph Virchow performed iodine staining,...
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