皮质体积的变化和复杂性在帕金森病与抑郁症中的变化
Jiaying Yuan1, Yujing Liu1, Haiyan Liao1,2
1Department of Radiology, The Second Xiangya Hospital, Central South University, Changsha, China.
CNS neuroscience & therapeutics
|February 29, 2024
概括
与没有抑郁症 (PDND) 相比,患有抑郁症的帕金森病 (PDD) 在关键大脑区域显示出显著的皮质缩. 这些PDD的结构变化为帕金森病中抑郁症的机制提供了洞察力.
科学领域:
- 神经成像是一种神经成像.
- 神经学 神经学
- 精神病学是一个精神病学.
背景情况:
- 帕金森病 (PD) 是一种神经退行性疾病,通常伴有抑郁症.
- 了解PD中抑郁症的神经生物学基础对于有效治疗至关重要.
研究的目的:
- 为了调查帕金森病与抑郁症 (PDD) 和帕金森病没有抑郁症 (PDND) 患者之间的灰质体积和皮质复杂性的差异.
- 探索PDD中大脑结构和抑郁症状之间的关系.
主要方法:
- 基于voxel的形态测量 (VBM) 和基于表面的形态测量 (SBM) 用于分析脑部扫描.
- 一向ANOVA在PDND,PDD和健康对照 (HC) 组中比较了灰质体积和皮质复杂性.
- 研究人员检查了大脑指标和汉密尔顿抑郁量表-17 (HAMD-17) 评分之间的相关性.
主要成果:
- 与HC和PDND组相比,PDD患者表现出与HC和PDND组相比,额叶-叶-叶,叶,副海马回环和海马体的显著皮质缩.
- 在PDD中,在岛屿和背侧皮质中观察到缩指数的下降.
- 在PDD组中观察到左前骨灰质体积和HAMD-17分数之间存在显著负相关的趋势.
结论:
- 后期发育障碍 (PDD) 与岛内,头骨-骨-部和海马区域的广泛皮质结构变化有关.
- 这些发现为了解帕金森病中的抑郁症提供了形态基础.
- 这项研究强调了考虑到PD抑郁症病理生理学中的大脑结构变化的重要性.
相关概念视频
Parkinson's Disease: Overview
544
Neurodegenerative disorders are progressive diseases that cause irreversible damage and loss to neurons in specific brain areas. Examples of these disorders include Parkinson's disease, Alzheimer's disease, Multiple Sclerosis (MS), and Amyotrophic Lateral Sclerosis (ALS). These disorders share characteristics such as proteinopathies, selective neuronal vulnerability, and a complex interplay between genetic and environmental factors. The primary therapeutic goal for these conditions is...
544
Parkinson's Disease: Treatment
268
Neurodegenerative disorders, such as Parkinson's Disease (PD), involve the gradual and irreversible destruction of neurons in particular brain areas. These disorders exhibit standard features like proteinopathies, selective vulnerability of some neurons, and an interaction of intrinsic properties, genetics, and environmental influences in neural injury.
Parkinson's Disease is primarily a result of the loss of dopaminergic neurons in the substantia nigra pars compacta. The cornerstone of...
Parkinson's Disease is primarily a result of the loss of dopaminergic neurons in the substantia nigra pars compacta. The cornerstone of...
268
Neural Regulation
39.4K
Digestion begins with a cephalic phase that prepares the digestive system to receive food. When our brain processes visual or olfactory information about food, it triggers impulses in the cranial nerves innervating the salivary glands and stomach to prepare for food.
39.4K
Alzheimer's Disease: Overview
481
Alzheimer's Disease (AD) is a continually advancing neurodegenerative disorder, distinguished by escalating memory loss, cognitive dysfunction, and dementia. The disease unfolds in three stages: preclinical, mild cognitive impairment (MCI), and dementia. Its onset is insidious, and the progression gradual, with the cause not well explained by other disorders.
The clinical diagnosis of AD hinges on the presence of memory and other cognitive impairments. Biomarkers, such as changes in Aβ...
The clinical diagnosis of AD hinges on the presence of memory and other cognitive impairments. Biomarkers, such as changes in Aβ...
481
Depressive Disorders: Etiology
94
Depressive disorders result from a complex interplay of biological, psychological, and sociocultural factors, each contributing uniquely to the development and persistence of the condition. Understanding these factors provides critical insight into the multifaceted nature of depression.
Biological Factors in Depression
Biological predispositions significantly influence the risk of developing depressive disorders. Genetic studies highlight the role of variations in the serotonin transporter...
Biological Factors in Depression
Biological predispositions significantly influence the risk of developing depressive disorders. Genetic studies highlight the role of variations in the serotonin transporter...
94
Depressive Disorders: MDD and Dysthymia
127
Depressive disorders are a group of mental health conditions characterized by pervasive feelings of sadness, diminished pleasure in life, and a significant impact on daily functioning. These conditions are most prevalent in individuals during their 30s and affect women at twice the rate of men. Contrary to popular belief, younger individuals are generally more susceptible to these disorders than older adults. Two key types of depressive disorders include Major Depressive Disorder (MDD) and...
127


