在接受自身造血干细胞移植的患者中,营养摄入量,身体组成和手握强度的变化:一项回顾性研究
Erik Rupnik1, Karmen Grasic Lunar1, Matjaz Sever1,2
1Department of Hematology, University Medical Centre Ljubljana, Ljubljana, Slovenia.
Nutrition and cancer
|February 29, 2024
概括
接受自身造血干细胞移植 (autoHSCT) 的患者往往减少了口服摄入量,并经历了显著的体重减轻和肌肉衰竭. 热量不足与较差的结果相关,包括更长的住院时间和中性粒细胞移植延迟.
科学领域:
- 在瘤学瘤学.
- 营养科学 营养科学
- 移植医学 移植医学
背景情况:
- 自主造血干细胞移植 (autoHSCT) 是各种癌症和血液学疾病的关键治疗方法.
- 接受自动HSCT的患者经常患有口服摄入量减少和随后的营养不良,影响恢复.
- 了解营养状况及其与治疗结果的相关性对于改善移植后患者护理至关重要.
研究的目的:
- 为量化自动HSCT后患者的每日营养摄入量.
- 为了评估自动HSCT后的身体组成和肌肉力量的变化.
- 探索营养缺陷和临床结果之间的关系,包括移植和住院时间.
主要方法:
- 64名接受了自动HSCT的患者的回顾性分析.
- 使用食物记录和PN处方评估口服和肠道营养 (PN) 摄入量.
- 从饮食师记录中评估身体组成和手握强度.
主要成果:
- 平均口服摄入量为62%的需求,经常补充PN.
- 患者的平均体重损失为2.9公斤,瘦肉量为2.3公斤.
- 观察到手握力显著降低 (平均3.5公斤).
- 卡路里不足与减肥和手握强度下降有积极的相关性.
- 热量不足与中性粒细胞移植的时间和住院时间负相关.
结论:
- 在自动HSCT后的患者中,口服营养摄入量大幅减少.
- 热量不足与不良的临床结果有关,包括受损的康复和长时间住院治疗.
- 需要进一步的研究,以阐明营养缺乏对自动HSCT结果的影响,并制定有针对性的干预措施.
相关概念视频
Bone Marrow Sampling and Transplants
330
Bone marrow transplant is a potential cure for several diseases, including cancer and specific genetic disorders. Notably, this procedure is applicable for patients suffering from aplastic anemia, certain types of leukemia, severe combined immunodeficiency disease (SCID), Hodgkin's disease, non-Hodgkin's lymphoma, multiple myeloma, thalassemia, sickle-cell disease, and certain cancers.
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy...
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy...
330
Regulation of Hematopoietic Stem Cells
3.2K
All blood and immune cells are produced from the multipotent hematopoietic stem cells (HSCs) by the process of hematopoiesis. However, they all have a limited life span. In addition, many are depleted in immune surveillance or combatting an injury or infection. This makes blood one of the most regenerative tissues. Hematopoiesis helps replenish these blood and immune cells, restoring the body's normal functioning. However, overproduction of blood and immune cells can make them cancerous or...
3.2K
Multipotency of Hematopoietic Stem Cells
3.1K
The hematopoietic stem cells or HSCs are multipotent, meaning they can differentiate and give rise to all blood and immune cells. HSCs are maintained in the quiescent stage until an external stimulus initiates their differentiation. The multipotent HSCs exist as two heterogeneous populations, long-term repopulating cells (LTRC) and short-term repopulating cells (STRC). The two HSC populations have different surface markers or receptors and are classified based on quiescence and long-term...
3.1K
Stem Cell Therapy for Tissue Regeneration
4.0K
Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
Types of Stem Cells used in Stem Cell Therapy
The two main cell...
Types of Stem Cells used in Stem Cell Therapy
The two main cell...
4.0K
Hematopoiesis
5.3K
The process of blood cell formation is called hematopoiesis. Hematopoiesis starts early during development, on the seventh day of embryogenesis. This phase of hematopoiesis is called the primitive wave, wherein the extraembryonic yolk sac allows the production of erythroid cells and endothelial cells from a common precursor called hemangioblast. The erythroid cells provide oxygen to support the growth of the rapidly dividing embryo. Hemangioblasts later develop into hematopoietic stem cells or...
5.3K
Role of Hematopoietic Growth Factors
1.4K
Hematopoietic growth factors are molecules that regulate the differentiation rate of hematopoietic stem cells (HSCs). Erythropoietin (EPO), primarily produced by the kidneys, plays a crucial role in erythrocyte production. When oxygen levels in the blood are low, EPO is released into the bloodstream, reaching the bone marrow, where it stimulates HSCs to differentiate and mature into erythrocytes, which are vital for oxygen transport.
Thrombopoietin (TPO), mainly released by the liver,...
Thrombopoietin (TPO), mainly released by the liver,...
1.4K


