拉克诺酸A-F:来自型拉克诺物种的两酸原体
Kunthida Phutthacharoen1,2, Rita Toshe1,3, Syeda J Khalid1,3
1Department of Microbial Drugs, Helmholtz Centre for Infection Research GmbH (HZI), Inhoffenstraße 7, 38124, Braunschweig, Germany.
Chemistry & biodiversity
|February 29, 2024
概括
研究人员发现了六种新的氨基酸类似物,即酸A-F,来自 Lachnum sp. 的真菌. 拉克努酸A对黄金葡萄球菌和细菌细菌表现出强大的抗菌活性.
科学领域:
- 自然产品化学 自然产品化学
- 菌类学 菌类学是指菌类学.
- 有机化学 有机化学
背景情况:
- 型真菌是新型生物活性化合物的丰富来源.
- 菌属Lachnum尚未对其化学成分进行广泛研究.
研究的目的:
- 从真菌Lachnum sp.中分离和描述新的化学实体. 在IW157.7.
- 评估分离化合物的生物活性.
主要方法:
- 使用光谱技术 (NMR,HR-ESI-MS) 对真菌提取物进行化学探测.
- 结构阐明,包括相对和绝对配置的确定 (ROESY,莫舍尔).
- 生物活性测定:细胞毒性,抗菌性,抗菌膜和杀菌性.
主要成果:
- 六种前所未有的酸类似物,酸A-F (1-6),被分离和特征.
- 拉克努酸A (1) 呈现出强大的抗菌活性,可对抗金黄色葡萄球菌和细菌 (MIC分别为16.6和8.3微克/毫升).
结论:
- 拉姆特种公司 (Lachnum Sp. IW157生产的新型氨基酸类似物.
- 拉克努酸A是一种有前途的抗微生物药物,具有针对格拉姆阳性细菌的活性.
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