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用纳塔利祖马布治疗的高活性多发性硬化症患者中二次进展的风险:现实生活中的研究

Louisa Scherer¹, Marc Soudant², Sophie Pittion-Vouyovitch¹

¹Department of Neurology, Nancy University Hospital, 54035, Nancy, France.

Journal of neurology

|February 29, 2024

概括

多发性硬化症中二次进展的风险在纳塔利祖马布治疗时较低. 然而,在不切换到另一种强效疗法的情况下停止纳塔利祖马布,会显著增加这种风险.

科学领域:

神经学神经学
免疫学免疫学免疫学
临床试验临床试验

背景情况:

复发性多发性硬化症 (MS) 的管理旨在防止其次要进展.
纳塔拉利祖马布是MS的治疗选择,但其对进展风险的长期影响需要研究.

研究的目的:

评估纳塔利祖马布治疗复发性多发性硬化症患者的二次进展风险.
确定影响纳塔利祖马布治疗期间二次进展风险的因素.

主要方法:

这是一项基于登记册的队列研究,对574名复发性多发性硬化症患者进行了登记册Lorrain des Scléroses en Plaques (ReLSEP) 的研究.
患者在2002年至2021年期间至少接受过一次纳塔利祖马布输液.
使用标准化定义和多状态模型分析了二次进展的风险,确定因素使用考克斯回归.

主要成果:

在平均6.7年的时间里,304名患者在进展之前停止了纳塔利祖马布.
在那些停止使用纳塔利祖马布的人群中,10年后累计进展的概率为28.3%.
停用纳塔利祖马布而不转向高活性治疗增加了进展风险 (aHR=2.7),而这种治疗降低了风险 (aHR=0.42).

结论:

纳拉利祖马布治疗与MS中二次进展的风险相对较低有关.
停止纳塔利祖马布治疗,特别是如果不转向高活性免疫抑制剂,则会增加二次进展的风险.

关键词:

多发性硬化症是多发性硬化症.娜塔莉莎表示观察性研究是一种观察性研究.二次进展的二次进展.

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