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用免疫检查点抑制剂治疗的患者的胰腺损伤:一项回顾性多中心研究
Kae Nagao1, Arata Sakai2, Hidetaka Tsumura3
1Division of Gastroenterology, Department of Internal Medicine, Kobe University Graduate School of Medicine, 7-5-1 Kusunoki-cho, chuo-ku, Kobe, Hyogo, 650-0071, Japan.
Journal of gastroenterology
|February 29, 2024
概括
免疫检查点抑制剂相关的胰腺损伤 (ICI-PI) 是罕见的,影响1.8%的患者. 在类固醇治疗期间.
科学领域:
- 在瘤学瘤学.
- 免疫学 免疫学 免疫学
- 胃肠病学 胃肠病学
背景情况:
- 免疫检查点抑制剂 (ICI) 越来越多地用于癌症治疗.
- 免疫检查点抑制剂相关的胰腺损伤 (ICI-PI) 是一种罕见但可能严重的不良事件.
- 详细的临床特征,风险因素和ICI-PI的治疗结果尚未确立.
研究的目的:
- 为了确定ICI-PI的临床特征.
- 确定与ICI-PI相关的风险因素.
- 评估ICI-PI的治疗策略和结果.
主要方法:
- 这是一项回顾性多中心研究,涉及1069名接受ICI治疗的患者.
- 使用CTCAE ver.识别患有胰腺酶或胰腺炎升高的患者. 5.0 标准. 这就是5.0标准.
- 对被诊断患有ICI-PI (≥3级酶升高或胰腺炎) 的患者进行详细分析.
主要成果:
- ICI-PI发生在1.8%的患者中;胰腺炎发生在0.5%.
- 一名患者患有严重的胰腺炎,导致死亡.
- 类固醇治疗显示不清楚的益处;ICI再试验在大多数康复后的患者中是安全的.
结论:
- ICI-PI是一种罕见的不良事件,胰腺炎的发病率很低.
- 类固醇治疗在ICI-PI管理中的作用需要进一步调查.
- 在ICI-PI解析后,重新挑战ICI患者是可行的,并且通常是安全的.
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