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Updated: Jul 2, 2025

In Vivo Nanovector Delivery of a Heart-specific MicroRNA-sponge
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Published on: June 15, 2018

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微RNA治疗模仿物的化学修饰模式:关于miR-200c的结构-活性关系 (SAR) 案例研究

Marion Garreau1, Julie Weidner2, Russell Hamilton3

  • 1Medicinal Chemistry, Research & Early Development, Respiratory & Immunology, BioPharmaceutical R&D, AstraZeneca, Gothenburg, Sweden.

Nucleic acids research
|February 29, 2024
PubMed
概括

这项研究探讨了合成微RNA (miRNA) 模仿物的化学修饰,以提高它们的稳定性和有效性. 优化的修改模式提高了治疗应用的miRNA模仿性能.

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MicroRNAs01:22

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