在BRCA1和BRCA2序列变异的妇女中,MRI监测和乳腺癌死亡率
Jan Lubinski1, Joanne Kotsopoulos2,3, Pal Moller4
1International Hereditary Cancer Center, Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland.
磁共振成像 (MRI) 监测显著降低了BRCA1基因变异的女性乳腺癌死亡率. 需要进一步的研究来证实BRCA2变异女性的类似益处.
科学领域:
- 在瘤学瘤学.
- 遗传学 是一个遗传学.
- 放射学 放射学是指放射学
背景情况:
- 患有BRCA1或BRCA2基因病原性变异的女性,一生患乳腺癌的风险较高.
- 磁共振成像 (MRI) 监测用于在这些高风险个体中早期检测乳腺癌.
- 磁力共振成像监测对这一群体乳腺癌死亡率的影响需要进一步定义.
研究的目的:
- 为了比较BRCA1/BRCA2变异的接受MRI监测和未接受MRI监测的女性之间的乳腺癌死亡率.
- 评估MRI监测在降低高风险女性乳腺癌死亡率方面的有效性.
主要方法:
- 分析了来自11个国家的59个中心的2488名患有BRCA1或BRCA2变异的女性队列.
- 参与者从30岁到75岁,死亡或最后的随访期间进行了跟踪,通过问卷收集数据.
- 考克斯比例危险建模用于评估MRI监测与乳腺癌死亡率之间的关联.
主要成果:
- 在平均9.2年的随访期间,344名女性患上了乳腺癌,35人死于乳腺癌.
- 在BRCA1变异的妇女中,MRI监测与乳腺癌死亡率显著降低有关 (HR=0.20).
- 在BRCA2变异的女性中没有发现显著的关联 (HR=0.87).
结论:
- 核磁共振扫描监测与BRCA1变异女性乳腺癌死亡率显著降低有关.
- 需要进行额外的研究来确定BRCA2变异的女性是否会从MRI监测中获得类似的死亡益处.
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