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来自的原始多糖化合物引起一种抗过敏作用对抗1型过敏在体外
Omoanghe S Isikhuemhen1, Felicia N Anike2, Judith O Enemudo3
1Mushroom Biology and Fungal Biotechnology Laboratory, Department of Natural Resources and Environmental Design, College of Agriculture and Environmental Sciences, North Carolina Agricultural and Technical State University, Greensboro, NC 27411, USA.
International journal of medicinal mushrooms
|February 29, 2024
概括
中的多糖体显示出作为替代过敏疗法的潜力. 菌髓的提取物,特别是Inonotus obliquus,显著降低了巨细胞脱粒化,表明它具有抗过敏性质.
科学领域:
- 菌类学 菌类学是指菌类学.
- 免疫学 免疫学 免疫学
- 药理学 药理学是指药理学的学科.
背景情况:
- 1型过敏性疾病是一个全球性健康挑战,推动了对新疗法战略的研究.
- 因其药用特性而得到认可,但它们的抗过敏潜力,特别是来自果实体 (FB) 和菌根的多糖,仍然未被充分探索.
研究的目的:
- 为了研究从选定的物种的果实体 (FB) 和菌中提取的原始多糖的体外抗过敏特性.
- 为了评估这些真菌多糖的抑制作用对巨细胞脱粒化.
主要方法:
- 使用Caco-2和RBL-2H3细胞的体外共同培养系统被用于模拟过敏反应.
- 测量β-hexosaminidase的释放,这是一种巨细胞脱粒的标志物,以评估抗过敏活性.
主要成果:
- 来自Inonotus obliquus果实体的原始多糖体显示,β-hexosaminidase释放的16%显著减少.
- 虽然Lentinus squarrosulus和Pleurotus ostreatus的果实体中的多糖体没有显著的影响,但它们的菌根提取物达到高达23%的减少.
- 与相应的果实体提取物相比,菌素提取物通常表现出更强大的抗脱粒活性.
结论:
- 精选的多糖,特别是来自菌的多糖,具有显著的抗过敏特性.
- 这些发现表明,衍生的多糖可能是开发1型过敏疾病的替代疗法的宝贵资源.
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