基于自然杀手T细胞的癌症免疫疗法的进展:使用异构和基因编辑细胞
Takahiro Aoki1, Shinichiro Motohashi1
1Department of Medical Immunology, Graduate School of Medicine, Chiba University, Chiba, Japan.
Critical reviews in oncogenesis
|February 29, 2024
概括
使用捐赠细胞的全基性免疫细胞疗法比患者特异性治疗提供了优势. 自然杀手T (NKT) 细胞疗法对癌症治疗有前途,但需要进一步研究.
科学领域:
- 免疫学 免疫学 免疫学
- 在瘤学瘤学.
- 细胞疗法细胞疗法
背景情况:
- 目前的仿真抗原受体T细胞疗法由于个性化制造而昂贵且耗时.
- 全基性免疫细胞疗法提供了一个具有现成可用性和标准化生产的替代方案.
- 自然杀伤性T (NKT) 细胞不受HLA限制,具有抗癌细胞毒性,因此适合用于全基性免疫疗法.
结论:
- 全基性NKT细胞有可能彻底改变癌症治疗.
- 进一步的研究和临床试验对于确定疗效,安全性和长期益处至关重要.
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