在NKT授权的活体基细胞基免疫疗法作为癌症治疗的细胞免疫药物
Shin-Ichiro Fujii1, Kanako Shimizu1
1Laboratory for Immunotherapy, RIKEN Center for Integrative Medical Sciences (IMS), and RIKEN Program for Drug Discovery and Medical Technology Platforms, Yokohama, Kanagawa, Japan.
Critical reviews in oncogenesis
|February 29, 2024
概括
人工辅助载体细胞 (aAVCs) 通过结合瘤抗原和CD1d-不变的自然杀手T (iNKT) 细胞连接体,提供了一种新的免疫疗法方法. 该战略旨在增强先天性和适应性免疫力,以改善癌症治疗结果.
科学领域:
- 免疫治疗是一种免疫疗法.
- 细胞免疫学 细胞免疫学
- 癌症治疗方法 癌症治疗方法
背景情况:
- 免疫疗法,特别是使用树突细胞 (DC) 和自然杀伤性T (NKT) 细胞,是一种关键的癌症治疗方式.
- 之前的方法涉及带有NKT连接体或NKT细胞转移的ex vivo培养DC,需要进行协议优化.
- 通过将天生的免疫和适应性免疫联系起来,针对现场的DCs对于防止瘤免疫逃脱至关重要.
研究的目的:
- 介绍和讨论人工辅助载体细胞 (aAVC) 疗法,一个全合一的,现成的药物.
- 为了证明DC/GalCer和NKT转移疗法的疗效.
- 探索aAVC在现场DC成熟,瘤微环境重编程和长期T细胞记忆诱导方面的潜力.
主要方法:
- 已建立的人工辅助载体细胞 (aAVCs),包括瘤抗原和CD1d不变的自然杀手T (iNKT) 连接体复合体.
- 评估了DC/GalCer疗法和NKT转移疗法.
- 进行了第一个人类临床试验,使用WT1抗原表达的aAVC对抗急性髓性白血病.
主要成果:
- 已证明aAVC疗法可有效诱导先天性和适应性免疫.
- 描述了aAVC在局部瘤微环境重编程和全身T细胞记忆诱导中的作用.
- 成功启动了针对复发性/耐药性急性髓性白血病的第一个人类临床试验.
结论:
- aAVCs代表了一种有前途的前药物策略,用于活体中积极激活DCs.
- aAVC治疗是免疫网络的基础,并有可能为患者提供最大的益处.
- 需要进一步开发,以应对挑战,并优化AVC应用的战略.
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