85岁个体的正静性低血压和认知功能:瑞典的一项纵向队列研究
Peder af Geijerstam1,2, Katie Harris2, Maria M Johansson3,4
1Department of Health, Medicine and Caring Sciences, Faculty of Medicine and Health Sciences, Linköping University, Linköping, Sweden.
Aging and disease
|February 29, 2024
概括
85岁的人的正静性低血压 (OH) 有不同的死亡风险. 延迟的OH使死亡风险增加一倍,而暂时的OH可能会降低死亡风险,与年轻人群不同.
科学领域:
- 老年学是一门学科.
- 心血管医学 心血管医学
- 流行病学 流行病学
背景情况:
- 静止性低血压 (OH) 在老年人中普遍存在,并与较高的死亡率有关.
- 在85岁及以上的个体中,OH对死亡率和发病率的具体影响仍然在很大程度上是未知的.
研究的目的:
- 调查不同类型的静止性低血压与非常老年人 (85岁以上) 的全因死亡率之间的关联.
主要方法:
- 前性观察队列研究 (ELSA 85) 追踪了从85岁起的496名个人.
- 血压被测定躺着和1,3,5分钟,站起来10分钟后.
- 根据血压反应模式,高血压被分为经典连续性,经典短暂性或延迟性.
主要成果:
- 在329名参与者中,47.4%患有经典性OH,4.6%患有延迟性OH.
- 延迟的OH与因任何原因死亡的风险增加了两倍 (HR 2.15).
- 过渡的经典OH显示了减少死亡率的趋势 (HR0.58),但经过调整后,这并不显著.
结论:
- 与年轻人相比,85岁人群的正静性低血压可能对死亡率有不同的影响.
- 延迟OH在非常老年人中具有显著的死亡风险.
- 需要进一步的研究,以了解不同OH亚型在老年时的多样化影响.
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