严重的眼内炎症在内发炎后Faricimab
Loka Thangamathesvaran1, Jun Kong1, Susan B Bressler1
1Department of Ophthalmology, Johns Hopkins University School of Medicine, Baltimore, Maryland.
JAMA ophthalmology
|February 29, 2024
概括
三名患者在接受内法利西马布注射后出现了严重的眼内炎症 (IOI). 这一案例系列强调了对法里西马布的持续监测的必要性.
科学领域:
- 眼科医生 眼科 眼科
- 视网膜疾病 视网膜疾病
- 药理学 药理学是指药理学的学科.
背景情况:
- 眼内炎症 (IOI) 监测对于评估新药的安全性至关重要.
- 较新的药物如布罗卢齐祖马布 (brolucizumab),佩格塞塔科普兰 (pegcetacoplan) 和法里西马布 (faricimab) 在临床实践中需要仔细评估风险和益处.
- 由于试验数据有限,因此需要对罕见不良事件进行市场后监测.
研究的目的:
- 描述三例急性,严重的后部段IOI在静脉内注射法里西马布后的情况.
- 报告最初在一个机构短时间内发生的文化负面IOI事件.
- 为了解与法利西马布治疗相关的潜在风险做出贡献.
主要方法:
- 一个案例系列设计被用来记录患者的经验.
- 在faricimab注射后发现了三名患有严重IOI的患者.
- 诊断程序包括视力敏度评估,培养玻璃体探和视网膜成像.
主要成果:
- 三名患者在静脉内注射法里西马布后3-4天内出现了急性,严重的前后段IOI.
- 在所有最初的探中,玻璃体培养都是负的; 一名患者的玻璃切除培养显示出可能的污染物.
- 症状在一个月内消失,视敏度恢复的程度各不相同.
结论:
- 在内法利西马布之后,这种严重IOI病例的群体表明事件可能比试验数据显示的更频繁.
- 潜在的未知存储或处理问题可能与这些炎症事件有关.
- 在faricimab后检测和报告IOI病例时保持警对于患者的安全至关重要.
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