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Updated: Jul 2, 2025

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时间溶解的胰岛素颗粒的净化显示了颗粒老化过程中的蛋白质和脂质变化

Martin Neukam1, Pia Sala2, Andreas-David Brunner3

  • 1Molecular Diabetology, University Hospital and Faculty of Medicine Carl Gustav Carus, TU Dresden, 01307 Dresden, Germany; Paul Langerhans Institute Dresden (PLID) of the Helmholtz Center Munich at the University Hospital Carl Gustav Carus and Faculty of Medicine of the TU Dresden, 01307 Dresden, Germany; German Center for Diabetes Research (DZD), 85764 Neuherberg, Germany.

Cell reports
|February 29, 2024
PubMed
概括

研究人员净化了不同年龄的胰岛素颗粒,以研究它们的分子变化. 较年轻的颗粒优先释放诸如kinesin-1重链 (KIF5b) 和Ras相关蛋白3a (RAB3a) 等蛋白质,揭示了对调节的外细胞形成的洞察力.

关键词:
在阿尔赫加普1上.这是一个CLIP标签.CP: 细胞生物学 细胞生物学CP:新陈代谢过程中的新陈代谢.KIF5bb的情况是这样的.在 RAB3a 中使用 RAB3a.这是一个SNAP标签.颗粒的老化 颗粒的老化胰岛素颗粒的胰岛素颗粒.脂质组的类型是什么器官细胞的净化和净化蛋白质组学 蛋白质组学

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