在扩张性心肌病中基于深度学习预测主要心律失常事件:概念验证研究
Mattia Corianò1, Corrado Lanera2, Laura De Michieli1
1Department of Cardiac, Thoracic, Vascular Sciences and Public Health, Padova, Italy.
PloS one
|February 29, 2024
概括
一个新的深度学习模型,DARP-D,显示了使用心脏MRI数据预测扩张性心肌病中主要心律失常事件的前景. 虽然可行,但在临床应用之前需要进一步的研究.
科学领域:
- 心脏病学 心脏病学
- 生物医学工程 生物医学工程
- 人工智能的人工智能
背景情况:
- 在扩张性心肌病中预测主要心律失常事件 (MAE) 是一个重大的临床挑战.
- 计算模型和人工智能 (AI) 在MAE预测方面提供了潜在的进步.
研究的目的:
- 开发和评估一个深度学习 (DL) 模型,DARP-D,用于预测和跟踪扩张性心肌病患者的MAE风险.
- 用多维心磁共振成像 (CMR) 数据和临床共变量来预测风险.
主要方法:
- 使用 cine 和 LGE CMR 图像/超图像和临床数据开发了一个 DL 模型 (DARP-D).
- 该模型在154名扩张性心肌病患者中的70%接受了培训和验证,并对剩余的30%进行了测试.
主要成果:
- DARP-D证明了分析心脏运动,组织特征和共变量的可行性,以预测个人MAE风险曲线.
- 该模型在Harrell的C一致性指数中达到95%的CI,在试验组中为0.12-0.68.
结论:
- DARP-D模型代表了一种新的,可行的原型,用于在扩张性心肌病中预测心律失常风险.
- 包括患者数量少和MAE在内的局限性需要进一步研究以进行临床验证和实施.
相关概念视频
Disturbances in Heart Rhythm
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Arrhythmia or dysrhythmia refers to an abnormal heart rhythm caused by a defect in the heart's conduction system. It can cause the heart to beat irregularly, too quickly, or too slowly, leading to symptoms like chest pain, shortness of breath, and fainting. Factors such as stress, caffeine, alcohol, nicotine, cocaine, certain drugs, congenital defects, diseases, and electrolyte abnormalities can trigger arrhythmias.
Arrhythmias are categorized by their speed, rhythm, and origin. A slow...
Arrhythmias are categorized by their speed, rhythm, and origin. A slow...
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Mechanism of Cardiac Arrhythmias
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Arrhythmias are irregular heart rhythms occurring when the heart's electrical impulses become abnormal. These disturbances can lead to various symptoms, depending on their severity and the underlying cause. Some common factors contributing to arrhythmias include hypoxia, ischemia, electrolyte imbalances, excessive catecholamine exposure, drug toxicity, and muscle overstretching. Arrhythmias can be classified into two main types based on the rate and site of origin of abnormal heart rhythms.
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Pulse rhythm
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Pulse rhythm refers to the pattern of pulsations within specific intervals, offering valuable insights into the regularity or irregularity of the heart's beats as observed through the pattern of pulsation within specific intervals. A regular pulse exhibits a consistent heart rate with uniform waveforms and pulsation force, variations of which can be classified as normal, weak, or bounding.
Conversely, an irregular pulse pattern is termed dysrhythmia, stemming from disruptions in cardiac...
Conversely, an irregular pulse pattern is termed dysrhythmia, stemming from disruptions in cardiac...
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