来自Streptomyces olindensis DAUFPE 562222 的不寻常的甲
Fernanda O Chagas1,2, Leandro M Garrido3, Raphael Conti1
1Faculdade de Ciências Farmacêuticas de Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto, SP 05508-070, Brazil.
Journal of natural products
|February 29, 2024
概括
菌株Streptomyces olindensis产生了新的重新排列的drimane sesquiterpenes,olindenones A-G. olindenone A的生物合成涉及甲基利酸盐路径和拟议的烯环酶介导的II型机制.
科学领域:
- 自然产品化学 自然产品化学
- 微生物的二次代谢物.
- 生物合成生物合成
背景情况:
- 在actinobacteria.glycosylated中,甘油酸是不常见的.
- 菌株Streptomyces olindensis DAUFPE 5622产生了一个新的类别的重新排列的drimane六烯:olindenones A-G.
- 奥林登 B-D 是氧化衍生物,而 E-G 是糖化的类似物.
研究的目的:
- 为了阐明olindenones的生物合成途径.
- 描述Streptomyces olindensis.产生的新型基.
- 为了研究四烯重新排列的机制.
主要方法:
- 13用于追踪代谢途径的C-同位素标记研究.
- 新型类的结构阐明.
- 生物信息分析以识别潜在的烯循环酶基因 (尽管在本研究中没有成功).
主要成果:
- 已证实,奥林登A生物合成通过甲基利二酸盐 (MEP) 途径发生.
- 有证据表明,奥林登A.的部分协调的重组机制.
- 提出了一种潜在的II型烯环酶介导机制,涉及碳酸驱动的循环和重新排列.
结论:
- 该研究提出了奥林登的详细生物合成路径,包括MEP路径和一种新的循环/重排机制.
- 负责奥林登生产的特定烯环酶基因仍未确定.
- 这项工作扩大了已知的类的多样性和它们在actinobacteria中的生物合成途径.
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