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Updated: Jul 2, 2025

In Vivo Functional Study of Disease-associated Rare Human Variants Using Drosophila
00:06

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Published on: August 20, 2019

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致病性GATA2遗传变异利用一个强制增强机制来扭曲多系差异化程序

Koichi R Katsumura1,2, Peng Liu2,3, Jeong-Ah Kim1

  • 1Wisconsin Blood Cancer Research Institute, Department of Cell and Regenerative Biology, Carbone Cancer Center, University of Wisconsin School of Medicine and Public Health, Madison, WI 53705.

Proceedings of the National Academy of Sciences of the United States of America
|February 29, 2024
PubMed
概括

生殖系GATA2变异会损害但不会取消GATA2基因调节,影响血细胞发育并增加白血病风险. 恢复C/EBPε部分纠正这些造血缺陷.

关键词:
这里是GATA GATA.在 GATA2 中.不同化的差异化差异化.血液形成 血液形成转录 转录 是一种转录.

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