MTHFD2表达在细胞癌的侵袭性方面的影响
Rafaela V N Silva1, Lucas A Berzotti1, Marcella G Laia1
1Department of Pathology, Genetics and Evolution, Institute of Biological and Natural Sciences, Federal University of Triângulo Mineiro, Uberaba, Minas Gerais, Brazil.
PloS one
|February 29, 2024
概括
甲基基酸脱酶2 (MTHFD2) 在癌亚型中表现多样. 虽然MTHFD2mRNA表明瘤预后和攻击性,但其蛋白质的预后价值需要在细胞癌 (RCC) 中进一步验证.
科学领域:
- 在瘤学瘤学.
- 分子生物学分子生物学
- 生物标志物发现发现
背景情况:
- 细胞癌 (RCC) 是一种常见的癌,通常是晚诊断的.
- 目前缺乏可靠的预后生物标志物用于RCC.
- 甲基基酸脱酶2 (MTHFD2) 的过度表达是RCC的潜在预后指标.
研究的目的:
- 为了研究不同RCC亚型的MTHFD2表达模式.
- 将MTHFD2表达与瘤特征和患者预后相关联.
- 为了澄清RCC中MTHFD2的蛋白质表达特征.
主要方法:
- 使用KM-Plotter工具进行基因表达分析,以求生存和非新生体 (NN) 与瘤的比较.
- 免疫组织化学评估117个RCC样本中的MTHFD2蛋白表达.
- 统计分析将MTHFD2表达与临床和病理数据联系起来.
主要成果:
- 瘤样本中的MTHFD2转录水平高于NN,特别是在转移性RCC中.
- 在透明细胞 (ccRCC) 和乳头细胞 (pRCC) 亚型中观察到明显的MTHFD2表达模式.
- MTHFD2过度表达与ccRCC和pRCC的总生存时间较短以及pRCC的无复发生存时间较短相关.
结论:
- 在RCC组织学亚型中,MTHFD2表现出在mRNA和蛋白质水平上的差异性表达模式.
- MTHFD2 mRNA水平似乎反映了瘤的预后和攻击性.
- 在更大的队列中进一步验证MTHFD2蛋白质的预后价值是有必要的.
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