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2型糖尿病患者的风险因素控制和心血管事件
Do Kyeong Song1, Young Sun Hong1, Yeon-Ah Sung1
1Department of Internal Medicine, Ewha Womans University School of Medicine, Seoul, Korea.
PloS one
|February 29, 2024
概括
控制心血管风险因素可以显著减少2型糖尿病患者心血管疾病 (CVD) 的发生. 风险因素管理对T2DM患者至关重要,特别是患有心脏脏疾病的患者,以预防心脏病死亡率.
科学领域:
- 心脏病学 心脏病学
- 内分泌学 在内分泌学.
- 腎臟病學 (nephrology) 是一種醫學專業.
背景情况:
- 患有2型糖尿病 (T2DM) 的患者面临心血管疾病 (CVD) 的风险增加.
- 针对风险因素的干预措施对于减轻糖尿病人群中心血管疾病事件至关重要.
- 了解风险因素控制对心脏病发病率对患有心脏病和没有心脏病的糖尿病患者的影响至关重要.
研究的目的:
- 根据糖尿病患者的心血管风险因子控制,根据心脏脏疾病的存在或不存在分层比较心血管疾病事件的发生率.
- 评估糖尿病患者风险因素控制程度与心血管疾病死亡率之间的关联,考虑到心状况.
主要方法:
- 对大量队列的分析:113,909名糖尿病患者和290,339名没有糖尿病的患者.
- 使用了来自国家健康保险服务 (NHIS) 的数据.
- 基于控制不良的风险因素数量和心脏脏疾病存在的CVD事件和死亡率的评估危险比率.
主要成果:
- 在糖尿病患者中,患有四个或五个控制不良的风险因素,心血管疾病事件的危险比为1.19 (95% CI,1.06-1.34) 患有心脏脏疾病和2.31 (95% CI,1.95-2.74) 没有,与没有风险因素的糖尿病患者相比.
- 在患有心病的糖尿病患者中,有四到五个控制不良的风险因素显著增加了心血管疾病死亡风险 (危险比,1.64;95% CI,1.18-2.30),与没有风险因素的患者相比.
- 较差的风险因素控制显示,在没有心脏脏疾病的糖尿病患者中,心脏病发病率较高.
结论:
- 有效控制心血管风险因素可明显降低糖尿病患者心血管疾病事件发生率.
- 风险因素管理对于没有心脏脏疾病的糖尿病患者尤其具有影响力.
- 心血管风险因子控制的程度是糖尿病患者心血管疾病死亡率的重要预测指标,特别是那些先前患有心脏脏疾病的人.
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