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Updated: Jul 2, 2025

Optogenetic Phase Transition of TDP-43 in Spinal Motor Neurons of Zebrafish Larvae
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通过RNA介导的核糖核蛋白组件控制TDP-43的核保留

Patricia M Dos Passos1, Erandika H Hemamali1, Lohany D Mamede1

  • 1Edward Doisy Department of Biochemistry and Molecular Biology, Saint Louis University School of Medicine, St. Louis, Missouri, United States of America.

PLoS biology
|February 29, 2024
PubMed
概括

神经退行性疾病中的TDP-43蛋白聚合与其细胞位置有关. RNA结合和自我组装成大型复杂物促进核保留,防止有害的细胞质积累.

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