荷尔蒙贝叶斯:一种新的贝叶斯框架,用于分析脉动激素动态
Margaritis Voliotis1, Ali Abbara2, Julia K Prague2,3,4
1Department of Mathematics and Living Systems Institute, College of Engineering, Mathematics and Physical Sciences, University of Exeter, Exeter, United Kingdom.
PLoS computational biology
|February 29, 2024
概括
我们开发了hormoneBayes,这是一个开放式的贝叶斯框架,用于分析黄素化激素 (LH) 脉动性,帮助诊断诸如PCOS和HA等生殖系统疾病. 该工具量化不确定性,并有助于个性化生殖健康护理.
科学领域:
- 内分泌学 在内分泌学.
- 计算生物学 计算生物学
- 生殖医学 生殖医学
背景情况:
- 下丘脑通过脉动性淋巴激素释放激素 (GnRH) 的分泌来调节生殖激素.
- 改变的GnRH脉动性与诸如多囊性卵巢综合征 (PCOS) 和下丘脑缺血症 (HA) 等生殖功能障碍有关.
- 化激素 (LH) 是GnRH的替代标记物,但其脉动性分析资源密集,缺乏可访问的软件.
研究的目的:
- 介绍hormoneBayes,一个新的开放访问贝叶斯框架,用于分析连续LH测量.
- 为了使LH脉动性和下丘脑GNRH动态的可靠评估.
- 为临床医生提供一种可访问的工具来诊断生殖激素功能障碍.
主要方法:
- 利用节的模型来模拟带动LH动态的下丘脑信号.
- 采用最先进的顺序蒙特卡洛方法进行参数推理.
- 应用框架来分析连续LH测量以评估脉动性.
主要成果:
- 荷尔蒙贝斯精确估计关键脉冲参数 (脉冲间隔,分泌/清除率) 并识别LH脉冲.
- 该方法在男性和女性的不同临床环境 (健康,更年期,HA,PCOS) 中区分LH脉动性模式.
- 对不确定性的量化估计是hormoneBayes框架的一个关键优势.
结论:
- 荷尔蒙贝斯提供了一个可靠的,开放式访问工具来分析LH脉动性.
- 该框架可以在不同的生殖健康和疾病状态中区分LH脉动性.
- 这种工具具有实时激素监测和个性化,数据驱动的生殖内分泌学临床护理的潜力.
相关概念视频
01:01Feedback Loops
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In most cases, excessive hormone production is prevented by negative feedback—a loop that starts with a stimulus inducing the release of a particular substance, like a hormone, to maintain a certain level before triggering a signal that results in a decrease in further release of the hormone.
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01:19Regulation of Hormone Secretion
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Regulation of hormone secretion is a finely tuned orchestration driven by various types of stimuli, encompassing neural, humoral, and hormonal signals. Environmental cues instigate neural stimuli, where action potentials traverse nerve fibers to reach their designated targets. An illustrative scenario is the body's response to stress, wherein the sympathetic nervous system releases epinephrine from the adrenal glands, inducing the well-known 'fight or flight' reaction.
Humoral...
Humoral...
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01:22Hormonal Regulation of the Menstrual Cycle
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The ovarian cycle regulates endometrial changes throughout a single menstrual cycle via the coordinated action of gonadotrophin-releasing hormone (GnRH) and gonadotrophins.
At puberty, GnRH begins a pulsatile release pattern, which triggers the anterior pituitary gland to secrete follicle-stimulating hormone (FSH) and luteinizing hormone (LH). The frequency and amplitude of GnRH pulses vary across the menstrual cycle, with faster pulses favoring LH release and slower pulses favoring FSH...
At puberty, GnRH begins a pulsatile release pattern, which triggers the anterior pituitary gland to secrete follicle-stimulating hormone (FSH) and luteinizing hormone (LH). The frequency and amplitude of GnRH pulses vary across the menstrual cycle, with faster pulses favoring LH release and slower pulses favoring FSH...
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01:22Target Cell Response to Hormones
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Hormones intricately bind to receptors on the surface or within target cells, initiating a cascade of cellular responses.
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Notably, the cellular response can be regulated by altering the number of receptors expressed in the cell. For example, prolonged exposure to elevated hormone levels results in a gradual decline or down-regulation in the number of receptors for that specific hormone on the cell surface. Conversely, in response to low hormone levels, cells may use up-regulation, producing an...
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01:30Hormonal Control of the Ovarian Cycle
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The ovarian cycle is meticulously regulated by the hypothalamic-pituitary-gonadal axis. This cycle orchestrates the release of a mature oocyte, essential for reproduction.
Before puberty, the hypothalamus releases GnRH in a low frequency, low amplitude pulsatile manner. This along with the immature hypothalamic-pituitary-gonadal axis activity, results in low estrogen levels and the absence of a fully functional ovarian cycle. At puberty, GnRH secretion increases in both frequency and...
Before puberty, the hypothalamus releases GnRH in a low frequency, low amplitude pulsatile manner. This along with the immature hypothalamic-pituitary-gonadal axis activity, results in low estrogen levels and the absence of a fully functional ovarian cycle. At puberty, GnRH secretion increases in both frequency and...
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01:30Pulse rhythm
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Pulse rhythm refers to the pattern of pulsations within specific intervals, offering valuable insights into the regularity or irregularity of the heart's beats as observed through the pattern of pulsation within specific intervals. A regular pulse exhibits a consistent heart rate with uniform waveforms and pulsation force, variations of which can be classified as normal, weak, or bounding.
Conversely, an irregular pulse pattern is termed dysrhythmia, stemming from disruptions in cardiac...
Conversely, an irregular pulse pattern is termed dysrhythmia, stemming from disruptions in cardiac...
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