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通过双重免疫疗法诱导耐久缓解在感染SHIV的ART抑制

So-Yon Lim1, Jina Lee1, Christa E Osuna1

  • 1Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.

Science (New York, N.Y.)
|February 29, 2024
PubMed
概括

在停止抗逆转录病毒治疗 (ART) 后,N-803和广泛中和抗体 (bNAbs) 有助于控制猿人免疫缺陷病毒 (SHIV). 这表明持续的艾滋病毒缓解不需要完全根除病毒.

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Retroviruses have a single-stranded RNA genome that undergoes a special form of replication. Once the retrovirus has entered the host cell, an enzyme called reverse transcriptase synthesizes double-stranded DNA from the retroviral RNA genome. This DNA copy of the genome is then integrated into the host’s genome inside the nucleus via an enzyme called integrase. Consequently, the retroviral genome is transcribed into RNA whenever the host’s genome is transcribed, allowing the...
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