在巴西亚马逊地区多药耐药结核病患者的水平功能水平和氧化应激标志物
C A Sales1, M C F Pinto-Silva1, J G Bardález-Rivera1
1Universidade Federal do Pará, Faculdade de Farmácia, Laboratório de Toxicologia, Belém, PA, Brasil.
Brazilian journal of biology = Revista brasleira de biologia
|February 29, 2024
概括
这项研究研究了巴西多药耐药结核病患者的肝脏和氧化应激标志物. 结果表明药物诱导的潜在肝损伤,突出进一步研究的需要.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 传染性疾病 传染性疾病
- 生物化学 生物化学
背景情况:
- 多药耐药结核病 (MDR-TB) 构成了全球重大卫生挑战.
- 肝毒性是抗结核治疗的已知并发症.
- 了解MDR-TB中肝功能和氧化应激之间的相互作用对于患者管理至关重要.
研究的目的:
- 在巴西患有MDR-TB的患者中,将肝酶水平与氧化应激标志物相关联.
- 在这个人群中评估肝脏变化和氧化应激标志物的患病率.
主要方法:
- 研究了一组来自巴西转诊医院的30名MDR-TB患者.
- 通过光谱测量,分析了全血样本的肝酶 (AST,ALT,Gamma-GT,性酸酶) 和氧化应激标记物 (catalase,glutathione).
主要成果:
- 患有MDR-TB的患者显示肝酶升高:AST (中位数为60.50U/L),ALT (中位数为80U/L),Gamma-GT (中位数为54U/L) 和性酸酶 (中位数为100U/L) (p<0.0001).
- 甲酶的中位数为6.94U/gHb,而谷氨酸的中位数为14.76μgml.
- 受影响最大的人口群体是18-29岁的男性.
结论:
- 这些发现表明,抗结核药物在MDR-TB患者中具有潜在的肝毒性作用.
- 建议使用更大的样本大小进行进一步的研究,以确定这种脆弱人群中肝损伤的预测因素.
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