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Updated: Jun 28, 2026

High Yield Purification of Plasmodium falciparum Merozoites For Use in Opsonizing Antibody Assays
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High Yield Purification of Plasmodium falciparum Merozoites For Use in Opsonizing Antibody Assays

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从Plasmodium falciparum中表达和净化活性石基酸脱酶

Bruno G Dalla Vecchia Morales1,2,3, Joseph Albert M Evaristo1, George A R DE Oliveira1,4

  • 1Oswaldo Cruz Foundation Rondônia (FIOCRUZ/RO), Laboratory of Bioinformatics and Medicinal Chemistry, BR 364, km 9,5, Centro, 76801-059 Porto Velho, RO, Brazil.

Anais da Academia Brasileira de Ciencias
|February 29, 2024
PubMed
概括

研究人员开发了第一个表达E. coli中活跃的Plasmodium falciparum shikimate dehydrogenase (PfSDH) 的方法. 这一突破有助于发现针对疟疾寄生虫的新型抗疟疾药物.

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Author Spotlight: Identifying Compensatory Pathways in Malaria Parasites Containing Hypomorphic Allele of Essential Protein Kinases

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相关概念视频

Malaria01:29

Malaria

Malaria pathogenesis in humans reflects a delicate interplay between parasite biology and host response. Clinical illness reflects a host’s immune response to the parasite’s asexual replication cycle, which is often asymptomatic in individuals with partial immunity. From the parasite's perspective, transmission between mosquito and human with minimal host pathology is evolutionarily advantageous. Among the six Plasmodium species infecting humans, P. falciparum and P. vivax dominate in global...