发达国家和发展中国家持续存在的麻疹
1Pediatric Infectious Diseases, David Geffen School of Medicine at UCLA, Mattel Children's Hospital UCLA, Los Angeles, CA.
Journal of the Pediatric Infectious Diseases Society
|February 29, 2024
概括
麻疹是一种严重的疾病,具有严重的并发症,包括死亡和脑炎. 接种疫苗非常有效,两剂可预防99%的病例,建议立即重新评估第二剂的时间.
科学领域:
- 儿科 儿科 儿科
- 传染性疾病 传染性疾病
- 疫苗学 疫苗学 疫苗学
背景情况:
- 麻疹在全球范围内仍然是流行病和流行病,尽管可以通过疫苗预防.
- 历史上,公众的看法低估了麻疹的严重程度.
- 麻疹与急性和延迟的并发症有关,挑战了反疫苗叙述.
研究的目的:
- 为了强调麻疹的严重并发症.
- 为了强调麻疹疫苗接种的有效性.
- 提出一个优化的疫苗接种计划.
主要方法:
- 审查有关麻疹流行病学,并发症和疫苗有效性的现有文献.
- 对麻疹相关的发病率和死亡率数据的分析.
- 评估目前和拟议的麻疹疫苗接种计划.
主要成果:
- 麻疹并发症包括急性问题 (腹,中耳炎,肺炎,脑炎,发作,死亡) 和延迟后续 (SSPE,免疫性失忆症).
- 急性麻疹的死亡率为每1000人中1-3人,脑炎的风险为每1000人中1人.
- 亚急性硬化大脑炎 (SSPE) 比以前认为的更常见,麻疹后的免疫失忆症对全球健康负担作出了重大贡献.
结论:
- 麻疹是一个严重的公共卫生威胁,具有严重的后果.
- 两剂麻疹疫苗在预防感染方面有效率为99%.
- 美国目前的麻疹疫苗第二剂量计划可能需要修订,建议在当前的4-6年间隔内提前 (4-6周后的第一剂量) 给药.
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