莫桑比克的H7N6高度致病性禽流感,2023年
Iolanda Vieira Anahory Monjane1, Hernâni Djedje1, Esmeralda Tamele1
1Directorate of Animal Science, Central Veterinary Laboratory, Agrarian Research Institute of Mozambique, Maputo, Mozambique.
Emerging microbes & infections
|February 29, 2024
概括
高致病性禽流感 (HPAIV) H7N6在莫桑比克商业层中被检测到. 基因分析显示,与南非H7N6菌株有很高的相似性,这表明有共同的起源和区域性疾病问题.
科学领域:
- 兽医病毒学 兽医病毒学
- 分子流行病学分子流行病学
- 疾病监测 疾病监测
背景情况:
- 禽流感对家禽业和粮食安全构成重大威胁.
- 及时发现和描述新型疫情对于有效的控制策略至关重要.
研究的目的:
- 报告莫桑比克首次发现高致病性禽流感病毒 (HPAIV) H7N6.
- 为了描述检测到的H7N6病毒的遗传构成和病原性.
- 调查疫情的潜在起源和区域影响.
主要方法:
- 实时和传统的逆转录聚合酶链反应 (RT-PCR) 进行初始查.
- 代表性病毒分离物的全基因组测序.
- 遗传学分析和病毒基因序列的比较,特别是HA分裂部位.
主要成果:
- 在莫桑比克的商业层中确认H7N6禽流感病毒.
- 序列分析确定了与高度致病性禽流感 (HPAI) 相一致的H7裂解部位动机.
- HA和NA基因与2023年5月在南非先前发现的H7N6病毒具有很高的遗传相似性 (99.4-99.7%).
结论:
- 莫桑比克H7N6 HPAIV疫情可能起源于或与南非检测到的病毒密切相关.
- 这一发现强调了跨境监测和南非疾病协调管理的重要性.
- HPAIV H7N6的存在对区域家禽健康,生物安全和粮食安全有重大影响.
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