导航多发性硬化症第一线治疗的终止:患者护理的范式转变
Nazire Pinar Acar Ozen1, Ece Gok Dursun2, Asli Tuncer1
1Hacettepe University Faculty of Medicine, Department of Neurology, Sihhiye, Ankara 06100, Turkey; Hacettepe University MS Research and Application Center, Turkey.
Multiple sclerosis and related disorders
|February 29, 2024
概括
停止用于多发性硬化症 (MS) 的注射性疾病修饰疗法 (DMT) 可能导致疾病活性,特别是在年轻患者中. 然而,在达到稳定后停止使用DMT可能会导致更有利的长期结果.
科学领域:
- 神经学 神经学
- 免疫学 免疫学 免疫学
背景情况:
- 回顾性研究 (2005-2016) 分析了多发性硬化症 (MS) 患者在停止注射第一线疾病修饰疗法 (DMT) 后的结果.
- 研究了影响治疗中止和影响疾病进展的因素.
研究的目的:
- 为了确定与多发性硬化症治疗中止相关的因素.
- 评估停止注射DMT对MS患者疾病进展的影响.
主要方法:
- 对2,270名至少两年接受注射DMT的患者进行了回顾性分析.
- 将药物分类为停药后稳定 (SAD) 和停药后复发 (RAD) 组.
- 利用生存分析和后勤回归来评估停药因素和结果.
主要成果:
- 三分之一的患者在停止治疗后保持稳定;40人经历了疾病活动.
- 停药时的年龄较大 (≥50岁) 与更高的稳定率 (80%) 相相关.
- 经过一段稳定的时间,停止使用DMT显示出更有利的疾病发展趋势.
结论:
- 停药时的年龄和停药的原因是MS疾病进展的关键预测因素.
- 在疾病稳定后停止治疗可能会导致更好的结果,支持个性化MS管理.
- 需要进一步的研究来验证这些发现,并指导MS治疗终止的临床实践.
相关概念视频
Drug Therapy
43
The advent of drug therapy has profoundly shaped modern mental health care, providing targeted treatments for a range of psychological disorders. Psychotherapeutic drugs, classified into antianxiety, antidepressant, and antipsychotic medications, address symptoms across anxiety disorders, mood disorders, and schizophrenia. While these medications have transformed patient outcomes, they require careful management due to their potential side effects and limitations.
Antianxiety Medications
Antianxiety Medications
43
Classification of Illness
7.5K
The meaning of illness is individualized to each person who experiences an alteration in health. In contrast, disease is a medical term indicating a pathological change in the structure and function of the body or mind. It is a condition that has specific symptoms and boundaries.
An illness is a response to a disease in which the person's level of functioning is changed compared with a previous level. The general classification of illness includes acute and chronic.
Acute illness is severe...
An illness is a response to a disease in which the person's level of functioning is changed compared with a previous level. The general classification of illness includes acute and chronic.
Acute illness is severe...
7.5K
Methods of Documentation VI: Case Management Model
573
The case management model is a multidisciplinary approach that involves healthcare professionals from diverse disciplines, such as physicians, nurses, therapists, social workers, and pharmacists, working collaboratively to address the various needs of patients. Each healthcare professional brings unique expertise and perspectives, contributing to a more comprehensive understanding of the patient's condition and tailoring treatment plans accordingly.
For example, a patient with a chronic...
For example, a patient with a chronic...
573
Community Based Intervention
43
Community-based interventions in mental health represent a paradigm shift from institution-centered care to treatments embedded within the fabric of local communities. By prioritizing inclusion and leveraging existing societal structures, this approach fosters a supportive environment conducive to addressing mental health challenges while promoting individual dignity and agency.
Foundations of Community Mental Health Programs
Central to the success of community-based interventions is the...
Foundations of Community Mental Health Programs
Central to the success of community-based interventions is the...
43
Psychosis: Goals of Pharmacotherapy
128
Antipsychotic drugs are a crucial treatment method for acute and chronic psychoses, bipolar illness, and behavioral disorders. The selection of these drugs depends on several factors, including the state of the disease, clinical judgment, possible drug interactions, and the patient's sensitivity to adverse effects. In immediate scenarios, such as delirium and dementia, short-term treatment with low doses of high-potency typical or atypical agents can effectively manage symptom exacerbation.
128
Issues And Trends In Healthcare Delivery System
5.6K
The issues and trends in healthcare delivery are constantly changing. The COVID-19 pandemic is one recent issue that wreaked havoc on healthcare systems, causing a shortage of healthcare workers, high demand for medicines and supplies, and increased medical expenditure due to a lack of insurance. Other issues include rising healthcare costs and care fragmentation.
Cost Containment
Payment for healthcare services has historically promoted adoption of costly and often unnecessary or inefficient...
Cost Containment
Payment for healthcare services has historically promoted adoption of costly and often unnecessary or inefficient...
5.6K


