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哪个结构产生悖论性 (REM) 睡眠:大脑干,下丘脑,杏仁体或皮质?

Pierre-Hervé Luppi¹, Amarine Chancel¹, Justin Malcey¹

¹INSERM, U1028, CNRS, UMR5292, Lyon Neuroscience Research Center, SLEEP Team "Physiopathologie des réseaux neuronaux responsables du cycle veille-sommeil", Lyon, France; University Claude Bernard, Lyon 1, Lyon, France.

Sleep medicine reviews

|February 29, 2024

概括

快速眼动 (REM) 睡眠的产生涉及复杂的大脑干,下丘脑和皮质电路. 本综述详细介绍了控制REM睡眠和肌肉衰竭的神经通路,强调它们在记忆巩固中的作用.

科学领域:

神经科学是一个神经科学.
睡眠研究睡眠研究
大脑干和下丘脑功能

背景情况:

悖论性睡眠 (PS),或快速眼动 (REM) 睡眠,是一种独特的状态,由REMs,EEG激活和肌肉衰竭标志着.
了解PS的神经基础对于理解睡眠调节及其在认知功能中的作用至关重要.

研究的目的:

审查大脑干,下丘脑,杏仁体和皮质结构在PS的起源中的贡献.
提出一种神经控制PS启动和维护的模型,包括肌肉衰竭.

主要方法:

综述现有关于PS神经解剖学和神经生理学的文献.
对参与PS调节的神经元通路和神经递质系统的分析.

主要成果:

在PS期间的肌肉衰竭被认为是由于庞丁背下垂体体核 (SLD) 质质神经元向腹中枢髓 (vmM) 前运动神经元投射的激活.
在腹侧周水管灰细胞 (vPAG) 和深层半脑网状核中的PS-off GABAergic神经元在清醒和慢波睡眠期间不激活SLDPS-on神经元.
后垂体MCH和GABAergicPS-on神经元抑制PS-off神经元启动PS,而像杏仁体这样的边缘结构有助于PS表达和记忆巩固.

结论:

PS生成是由一个分布式网络编排的,该网络从皮质延伸到髓层.
在PS期间的边缘结构激活表明PS在记忆巩固中的作用,可能表明PS需要处理记忆.
在不同大脑区域的PS开启和PS关闭神经元群体之间的相互作用决定了睡眠状态的周期性.

关键词:

克劳斯特勒姆 (Claustrum) 是一个关闭的场所.学习和记忆的学习和记忆黑色素缩激素缩激素是什么肌肉的肌肉衰竭是指肌肉的衰竭.脑后大脑皮层 (Retrosplenial cortex) 是一个脑后大脑皮层.超母细胞核的核

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