功能神经系统疾病中的过渡静止状态突出边缘共激活模式
Samantha Weber1, Janine Bühler2, Serafeim Loukas3
1Department of Neurology, Psychosomatic Medicine Unit, Inselspital Bern University Hospital, University of Bern, 3012 Bern, Switzerland; University of Zurich, Psychiatric University Hospital Zurich, Department of Psychiatry, Psychotherapy and Psychosomatics, 8032 Zurich, Switzerland; Translational Imaging Center (TIC), Swiss Institute for Translational and Entrepreneurial Medicine, 3010 Bern, Switzerland; Institute of Bioengineering, Ecole Polytechnique Fédérale de Lausanne (EPFL), 1015 Lausanne, Switzerland.
功能神经障碍患者表现出大脑网络动态的改变,特别是在突出边缘网络. 这些变化与压力生物标志物和症状持续时间相关,表明压力调节和网络集成受损.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 医疗成像医学成像
背景情况:
- 功能神经障碍 (FND) 历来与压力有关,但缺乏直接测试.
- 研究大脑网络动态和压力生物标志物的研究可以阐明FND的病理生理学.
研究的目的:
- 分析FND患者休息时的大规模脑网络动态.
- 检查这些动态,压力生物标志物 (皮质醇,粉酶) 和临床症状之间的关系.
主要方法:
- 79名FND患者和74名对照患者的休息状态fMRI.
- 在17个静态网络之间对静态和动态功能连接的层次分析.
- 部分最小方程相关性,将网络变化与生物标志物和临床评分联系起来.
主要成果:
- 患有FND的患者表现出异常的突出边缘网络连接,与改变的岛屿协同激活模式.
- 患者表现出与突出性,体运动和默认模式网络的参与度增加,与皮层下和多种皮层网络的参与度降低.
- 动态网络变化与患者的糖酶水平和症状持续时间相关.
结论:
- 改变的岛屿协同激活模式,压力生物标志物和临床数据表明压力调节和功能网络集成的相互连接机制.
- 这些发现支持在FND中注意力和感觉处理受损的概念.
- 在FND中确定了动态功能性大脑网络的改变,提供了新的病理生理学见解.
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