一个基于临床和计算机断层扫描的综合放射性特征模型,以分离良性和恶性膜溢出
Fangqi Cai1, Liwei Cheng2, Xiaoling Liao3
1Department of Respiratory and Critical Care Medicine, The People's Hospital of Guangxi Zhuang Autonomous Region, Nanning, China, caifangqi1122@163.com.
Respiration; international review of thoracic diseases
|February 29, 2024
概括
结合放射性和临床因素的新组合模型有效地区分了恶性流 (MPE) 和良性流 (BPE),提高了患有流 (PE) 患者的诊断准确度.
科学领域:
- 医疗成像医学成像
- 在瘤学瘤学.
- 肺部病理学 肺部病理学
背景情况:
- 从临床上来说,区分恶性流 (MPE) 和良性流 (BPE) 是一个很大的挑战.
- 准确的区分对于适当的患者管理和治疗至关重要.
- 计算机断层扫描 (CT) 成像为非侵入性诊断方法提供了潜力.
研究的目的:
- 开发和验证一个组合模型来区分MPE和BPE.
- 将CT图像中的放射性特征与临床因素相结合,以提高诊断性能.
主要方法:
- 对315名肺溢出 (PE) 患者的回顾性研究.
- 从CT图像中提取和选择最佳的放射性特征.
- 使用后勤回归,SVM和随机森林的放射性,临床和组合模型的开发.
- 使用ROC曲线,校准曲线和决策曲线分析 (DCA) 验证模型的区分能力.
主要成果:
- 开发了一个综合模型,整合了15个最佳放射性特征和6个临床因素 (年龄,输出横向性,公,CEA,CA125,NSE).
- 与放射性模型 (AUC: 0.876 培训, 0.774 测试) 和临床模型 (AUC: 0.850 培训, 0.820 测试) 相比,组合模型显示出更好的区分性能 (AUC: 0.932 培训, 0.870 测试).
- 在放射性模型中,SVM实现了最高的性能 (AUC: 0.876训练,0.774测试).
结论:
- 开发的组合模型显示了区分MPE与BPE的巨大潜力.
- 这种综合方法提供了一个强大的工具,以帮助临床医生诊断腹腔溢液.
- 需要进一步验证,以确定其在常规实践中的临床实用性.
相关概念视频
01:28Pleural Effusion II: Symptoms and Management
167
Pleural Effusion Overview
A pleural effusion is the abnormal collection of fluid between the parietal and visceral pleura layers of tissue that form the lining of the lungs and chest cavity. It can occur independently or due to surrounding parenchymal diseases, such as infection, malignancy, or inflammatory conditions.
Clinical Manifestations:
A pleural effusion is the abnormal collection of fluid between the parietal and visceral pleura layers of tissue that form the lining of the lungs and chest cavity. It can occur independently or due to surrounding parenchymal diseases, such as infection, malignancy, or inflammatory conditions.
Clinical Manifestations:
167
01:25Pleural Effusion I: Introduction
980
Pleural effusion is an abnormal fluid accumulation in the pleural cavity, a narrow space between the lungs and the chest wall. It is not a disease per se but rather a symptom or indication of an underlying disease. In normal circumstances, this space contains a small amount of fluid (5 to 15 mL), a lubricant facilitating the non-frictional movement of the pleural surfaces.
There are two main types of pleural effusion: transudative and exudative. They are differentiated using Light's...
There are two main types of pleural effusion: transudative and exudative. They are differentiated using Light's...
980